Role of Wnt Signaling in Central Nervous System Injury
Role of Wnt Signaling in Central Nervous System Injury
复制标题
DOI：
10.1007/s12035-015-9138-x
复制
发表时间：
2016-05-01
影响因子：
5.1
通讯作者：
Inestrosa, Nibaldo C.
中科院分区：
文献类型：
--
作者：
Lambert, Catherine;Cisternas, Pedro;Inestrosa, Nibaldo C.
中枢神经系统（CNS）对外部机械损伤高度敏感，其再生能力有限，部分原因是其无法修复受损的神经元或突触网络。中枢神经系统可能遭受不同类型的影响其功能和/或结构的外部损伤，包括中风、脊髓损伤和创伤性脑损伤。这些病理严重影响了全世界大量患者的生活质量，并且由于现有的治疗方法无效且效果有限，往往是致命的。上述病理的常见影响包括触发几种细胞和代谢反应以对抗损伤，包括血细胞浸润、炎症、神经胶质活化和神经元死亡。尽管这些反应的一些潜在分子机制已经被阐明，但在中枢神经系统损伤的背景下，驱动这些过程的机制尚不清楚。近年来，研究表明Wnt信号通路的激活可能在中枢神经系统损伤后的再生反应中起重要作用，激活多种保护机制，包括刺激神经发生、血脑结构巩固和脑认知功能的恢复。由于Wnt信号参与多种生理过程，损伤后其激活的推测积极作用可能成为中枢神经系统损伤新治疗方法的基础。
The central nervous system (CNS) is highly sensitive to external mechanical damage, presenting a limited capacity for regeneration explained in part by its inability to restore either damaged neurons or the synaptic network. The CNS may suffer different types of external injuries affecting its function and/or structure, including stroke, spinal cord injury, and traumatic brain injury. These pathologies critically affect the quality of life of a large number of patients worldwide and are often fatal because available therapeutics are ineffective and produce limited results. Common effects of the mentioned pathologies involves the triggering of several cellular and metabolic responses against injury, including infiltration of blood cells, inflammation, glial activation, and neuronal death. Although some of the underlying molecular mechanisms of those responses have been elucidated, the mechanisms driving these processes are poorly understood in the context of CNS injury. In the last few years, it has been suggested that the activation of the Wnt signaling pathway could be important in the regenerative response after CNS injury, activating diverse protective mechanisms including the stimulation of neurogenesis, blood brain structure consolidation and the recovery of cognitive brain functions. Because Wnt signaling is involved in several physiological processes, the putative positive role of its activation after injury could be the basis for novel therapeutic approaches to CNS injury.