Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression
Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression
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DOI：
10.2147/ndt.s50197
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Zima, Tomas
中科院分区：
文献类型：
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作者：
Bizik, Gustav;Bob, Petr;Zima, Tomas
最近的证据表明，神经系统和免疫系统之间相互作用的性质在抑郁症的发病机制中起着重要作用。具体地说，促炎细胞因子的改变与抑郁障碍的几种心理和神经生物学表现的发展有关，也与压力暴露有关。许多研究结果表明，肿瘤坏死因子α(TNF-α)是这些过程中的中心因素之一。因此，在目前的研究中，我们检验了这样一个假设，即与创伤应激和分离相关的慢性应激源的特定影响与肿瘤坏死因子-α水平的变化有关。对66例住院单相抑郁症患者(平均年龄43.1±7.3岁)进行抑郁心理测量(Beck抑郁问卷[BDI]-II)、创伤应激症状(创伤症状自评量表[TSC]-40)、心理躯体形式分离(DES)和躯体形式分离问卷[SDQ]-20，并进行血清肿瘤坏死因子-α的免疫化学检测。结果表明，肿瘤坏死因子-α与DES显著相关(Spearman R=-0.42，P
Recent evidence indicates that the nature of interactions between the nervous system and immune system is important in the pathogenesis of depression. Specifically, alterations in pro-inflammatory cytokines have been related to the development of several psychological and neurobiological manifestations of depressive disorder, as well as to stress exposure. A number of findings point to tumor necrosis factor alpha (TNF-alpha) as one of the central factors in these processes. Accordingly, in the present study, we test the hypothesis that specific influences of chronic stressors related to traumatic stress and dissociation are related to alterations in TNF-alpha levels. We performed psychometric measurement of depression (Beck Depression Inventory [BDI]-II), traumatic stress symptoms (Trauma Symptom Checklist [TSC]-40), and psychological and somatoform dissociation (Dissociative Experiences Scale [DES] and Somatoform Dissociation Questionnaire [SDQ]-20, respectively), and immunochemical measure of serum TNF-alpha in 66 inpatients with unipolar depression (mean age 43.1 +/- 7.3 years). The results show that TNF-alpha is significantly related to DES (Spearman R=-0.42, P