Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen.
Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen.
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发表时间：
1986-04
期刊：
影响因子：
11.2
通讯作者：
J. Delic;C. Bush;M. Peckham
中科院分区：
文献类型：
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作者：
J. Delic;C. Bush;M. Peckham
在大鼠中研究了精子发生对细胞毒性药物诱导的损伤的保护作用。每周给予4次盐酸丙卡巴肼（150 mg/kg，首次给药; 100 mg/kg，随后3次给药）后，在第8周和第11周观察到完全性生殖发育不全。预处理大鼠6周，加上持续治疗期间丙卡巴肼管理与庚酸睾酮，240微克/100克体重，导致在一个显着的保护精子发生。平均22%的曲细精管横截面在8周和11周时表现出精子发生，并在60%的这些再生小管中观察到发育中的精子细胞。这些结果提供的证据表明，化疗期间的精子发生的保护可能是通过雄激素治疗实现的。
Protection of spermatogenesis from cytotoxic drug-induced damage has been investigated in the rat. Complete germinal aplasia was observed at 8 and 11 weeks after four doses of procarbazine hydrochloride administered weekly (150 mg/kg, first dose; 100 mg/kg, 3 subsequent doses). Pretreatment of rats for 6 weeks plus continued treatment during procarbazine administration with testosterone enanthate, 240 micrograms/100 g body weight, resulted in a marked protection of spermatogenesis. A mean of 22% of seminiferous tubule cross-sections at both 8 and 11 weeks exhibited spermatogenesis, and developing spermatids were observed in 60% of these repopulating tubules at the later time. These results provide evidence that protection of spermatogenesis during chemotherapy may be achieved by androgen treatment.