Significant association between IL-32 gene polymorphisms and susceptibility to endometrial cancer in Chinese Han women
Significant association between IL-32 gene polymorphisms and susceptibility to endometrial cancer in Chinese Han women
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IL-32基因多态性与中国汉族女性子宫内膜癌易感性的显着相关性
DOI：
10.1007/s13277-015-3186-8
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发表时间：
2015-07-01
期刊：
影响因子：
--
通讯作者：
Xi, Mingrong
中科院分区：
文献类型：
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作者：
Yu, Xiuzhang;Zhou, Bin;Xi, Mingrong
白介素 32 (IL-32) 是一种促炎趋化因子，据报道与炎症、传染病甚至癌症有关。本研究旨在通过一项对 272 名子宫内膜癌患者和 337 名健康对照者进行的医院研究，探讨 IL-32 的两种基因变异（rs28372698 和 rs12934561）是否与中国汉族女性子宫内膜癌 (EC) 易感性相关。结果显示，EC患者rs28372698的TT基因型频率（P=0.012，OR=2.37，95% CI=1.32-4.28）和T等位基因频率（P=0.026，OR=1.320，95% CI=1.036-1.681）显着高于对照组。临床分析表明TT基因型频率与高临床分期和宫颈侵犯相关。此外，rs12934561的CC基因型频率（P=0.0077，OR=1.62，95% CI=1.05-2.50）和C等位基因频率（P=0.043，OR=1.269，95% CI=1.011-1.592）在EC患者中也显着高于对照组。分层分析显示，CC 基因型在子宫内膜样腺癌或无宫旁侵犯的 EC 中更为常见。本研究表明，IL-32 基因多态性与中国汉族女性 EC 易感性增加显着相关。
Interleukin-32 (IL-32), a pro-inflammatory chemokine, has been reported to be involved in inflammatory, infectious diseases and even cancers. This study aimed to investigate whether two genetic variants (rs28372698 and rs12934561) of IL-32 were associated with susceptibility to endometrial cancer (EC) in Chinese Han women by a hospital-based study with 272 EC patients and 337 healthy controls. Our results showed that the frequencies of TT genotype (P=0.012, OR=2.37, 95 % CI=1.32-4.28) and T allele (P=0.026, OR=1.320, 95% CI=1.036-1.681) of rs28372698 in EC patients were significantly higher than controls. Clinical analyses indicated the TT genotype frequency was relevant to high clinical stage and cervical invasion. Furthermore, the frequencies of CC genotype (P=0.0077, OR=1.62, 95 % CI=1.05-2.50) and C allele (P=0.043, OR=1.269, 95 % CI=1.011-1.592) of rs12934561 were also significantly higher in EC patients than controls. Stratification analyses revealed that CC genotype was more frequent in endometrioid adenocarcinoma or EC without parametrial invasion. This study demonstrates that IL-32 gene polymorphisms are significantly associated with increased EC susceptibility in Chinese Han women.