Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status.
Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status.
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DOI：
10.1155/2013/609705
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发表时间：
2013
影响因子：
--
通讯作者：
James SJ
中科院分区：
文献类型：
--
作者：
Frye RE;Melnyk S;Fuchs G;Reid T;Jernigan S;Pavliv O;Hubanks A;Gaylor DW;Walters L;James SJ
针对自闭症儿童代谢异常的治疗是有限的。以前我们报道过营养治疗能显著改善自闭症儿童的谷胱甘肽代谢。在这项研究中，我们评估了适应行为的变化，并确定这种变化是否与谷胱甘肽代谢的变化有关。37名被诊断患有自闭症和谷胱甘肽和甲基化代谢异常的儿童以开放标签方式接受每周两次75 μg/Kg甲钴胺和每日两次400 μg亚叶酸治疗3个月。在基线和治疗期结束时测量Vineland适应行为量表（VABS）和谷胱甘肽氧化还原代谢产物。在治疗期间，所有VABS分量表均显著改善，平均效应量为0.59，技能平均改善7.7个月。谷胱甘肽氧化还原状态的更大改善与表达性沟通、个人和家庭日常生活技能以及人际交往、娱乐休闲和应对社交技能的更大改善相关。年龄、性别和消退史不影响治疗反应。观察到的显着的行为改善和这些改善谷胱甘肽氧化还原状态之间的关系表明，针对氧化还原代谢的营养干预可能有利于一些自闭症儿童。
Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children diagnosed with autistic disorder and abnormal glutathione and methylation metabolism were treated with twice weekly 75 µg/Kg methylcobalamin and twice daily 400 µg folinic acid for 3 months in an open-label fashion. The Vineland Adaptive Behavior Scale (VABS) and glutathione redox metabolites were measured at baseline and at the end of the treatment period. Over the treatment period, all VABS subscales significantly improved with an average effect size of 0.59, and an average improvement in skills of 7.7 months. A greater improvement in glutathione redox status was associated with a greater improvement in expressive communication, personal and domestic daily living skills, and interpersonal, play-leisure, and coping social skills. Age, gender, and history of regression did not influence treatment response. The significant behavioral improvements observed and the relationship between these improvements to glutathione redox status suggest that nutritional interventions targeting redox metabolism may benefit some children with autism.