Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa.
Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa.
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DOI：
10.1097/iae.0b013e3181ac2418
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Tsang SH
中科院分区：
文献类型：
--
作者：
Lima LH;Cella W;Greenstein VC;Wang NK;Busuioc M;Smith RT;Yannuzzi LA;Tsang SH
分析色素性视网膜炎患者眼底自发荧光可见的超自发荧光环下方的视网膜结构。研究人员对 13 名年龄在 13 岁至 67 岁之间的视网膜色素变性患者的 24 只眼睛进行了研究。光感受器纤毛（也称为光感受器的内/外段连接、外核层和视网膜色素上皮）的完整性，通过谱域光学相干断层扫描（OCT）在环外部、跨环和内部进行评估。在中心凹区域内，眼底自发荧光未检测到异常。在环外，眼底自发荧光显示低自发荧光与光感受器/视网膜色素上皮变性相一致。环内正常中心凹眼底自发荧光区域的谱域 OCT 显示所有眼睛的视网膜结构完整，视网膜总厚度值在正常范围内。在所有眼睛中，在整个环上，观察到内/外节段连接破坏，并且外核层的厚度在离心方向上减小。在高自身荧光环之外，内/外节段连接处和外核层似乎不存在，并且有视网膜色素上皮变性的迹象。在色素性视网膜炎的中央高自体荧光环上发现内/外节段连接的破坏和外视网膜厚度的减少。视网膜色素上皮的外节吞噬作用对于形成高自身荧光环是必要的。
To analyze the retinal structure underlying the hyperautofluorescent ring visible on fundus autofluorescence in patients with retinitis pigmentosa. Twenty-four eyes of 13 patients with retinitis pigmentosa, aged 13 years to 67 years, were studied. The integrity of the photoreceptor cilia, also known as the inner/outer segment junction of the photoreceptors, the outer nuclear layer, and retinal pigment epithelium, was evaluated outside, across, and inside the ring with spectral-domain optical coherence tomography (OCT). Inside the foveal area, fundus autofluorescence did not detect abnormalities. Outside the ring, fundus autofluorescence revealed hypoautofluorescence compatible with the photoreceptor/retinal pigment epithelium degeneration. Spectral-domain OCT inside the ring, in the area of normal foveal fundus autofluorescence, revealed an intact retinal structure in all eyes and total retinal thickness values that were within normal limits. Across the ring, inner/outer segment junction disruption was observed and the outer nuclear layer was decreased in thickness in a centrifugal direction in all eyes. Outside the hyperautofluorescent ring, the inner/outer segment junction and the outer nuclear layer appeared to be absent and there were signs of retinal pigment epithelium degeneration. Disruption of the inner/outer segment junction and a decrease in outer retinal thickness were found across the central hyperautofluorescent ring seen in retinitis pigmentosa. Outer segment phagocytosis by retinal pigment epithelium is necessary for the formation of an hyperautofluorescent ring.