Diet, interleukin-17, and childhood asthma in Puerto Ricans
Diet, interleukin-17, and childhood asthma in Puerto Ricans
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DOI：
10.1016/j.anai.2015.07.020
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发表时间：
2015-10-01
影响因子：
5.9
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
--
作者：
Han, Yueh-Ying;Forno, Erick;Celedon, Juan C.
背景资料：饮食模式可能会影响哮喘的发病机制在波多黎各人，种族群体最受这种疾病的影响，在美国。目的：检查饮食，T辅助细胞17型细胞因子，和哮喘在波多黎各儿童之间的关联。方法：作为对圣胡安678名6至14岁的波多黎各儿童进行的病例对照研究的一部分，参与者完成了一份关于儿童前一周食物消耗量的75项问卷。食物被分为7组：水果，蔬菜，谷物，蛋白质食物，乳制品，脂肪和糖果。Logistic回归分析各组的饮食频率、血浆辅助性T细胞17型细胞因子水平和哮喘的关系。根据这一分析，（范围-2 [不健康饮食：高消费乳制品和甜食，低消费蔬菜和谷物]到+2 [健康饮食：高消费谷物和蔬菜，低消费乳制品和甜食]）被创建以识别饮食模式。谷物的高消费量与哮喘的低风险有关（调整后的比值比[aOR] 0.52，95%置信区间[CI] 0.33-0.82），而经常食用乳制品（aOR 1.93，95% CI 1.32-2.84）或甜食（aOR 1.82，95% CI 1.08-2.72）与哮喘的风险较高相关。更健康的饮食（食物评分每增加1分）与白细胞介素-17 F水平较低相关（β = -1.48 pg/mL，95% CI -1.78至-1.20），哮喘发生率降低36%（aOR 0.64，95% CI 0.53-0.77）。结论：健康饮食，经常食用蔬菜和谷物，少吃乳制品和糖果，与白细胞介素-17 F水平较低和波多黎各儿童哮喘发病率降低有关。(c)2015年美国过敏，哮喘和免疫学学院。爱思唯尔公司出版。All rights reserved.
Background: Dietary patterns might influence the pathogenesis of asthma in Puerto Ricans, the ethnic group most affected by this disease in the United States.Objective: To examine the association among diet, T-helper cell type 17 cytokines, and asthma in Puerto Rican children.Methods: As part of a caseecontrol study of 678 Puerto Rican children 6 to 14 years old in San Juan, participants completed a 75-item questionnaire on the child's food consumption in the prior week. Foods were aggregated into 7 groups: fruits, vegetables, grains, protein foods, dairy, fats, and sweets. Logistic regression was used to evaluate consumption frequency of each group, plasma T-helper cell type 17 cytokine levels, and asthma. Based on this analysis, a food score (range -2 [unhealthy diet: high consumption of dairy products and sweets, low consumption of vegetables and grains] to +2 [healthy diet: high consumption of grains and vegetables, low consumption of dairy and sweets]) was created to identify dietary patterns.Results: High consumption of grains was associated with lower odds of asthma (adjusted odds ratio [aOR] 0.52, 95% confidence interval [CI] 0.33-0.82), whereas frequent consumption of dairy products (aOR 1.93, 95% CI 1.32-2.84) or sweets (aOR 1.82, 95% CI 1.08-2.72) was associated with higher odds of asthma. A healthier diet (each 1-point increment in food score) was associated with lower levels of interleukin-17F (beta = -1.48 pg/mL, 95% CI -1.78 to -1.20) and with 36% decreased odds of asthma (aOR 0.64, 95% CI 0.53-0.77).Conclusion: A healthy diet, with frequent consumption of vegetables and grains and low consumption of dairy products and sweets, was associated with lower levels of interleulin-17F and decreased odds of childhood asthma in Puerto Ricans. (c) 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.