Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137 316: establishment of a regimen that permits normal menstrual cyclicity.
Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137 316: establishment of a regimen that permits normal menstrual cyclicity.
复制标题
用低剂量的抗孕激素 ZK 137 316 对雌性恒河猴进行慢性治疗：建立允许正常月经周期的治疗方案。
DOI：
10.1093/humrep/13.2.259
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Stouffer,RL
中科院分区：
文献类型：
--
作者：
Zelinski-Wooten,MB;Slayden,OD;Chwalisz,K;Hess,DL;Brenner,RM;Stouffer,RL
大剂量的抗孕激素通常会破坏月经周期。建立了一种长期低剂量的强效新抗孕酮ZK 137 316方案，该方案允许持续的月经周期，但会改变性腺生殖道活动。恒河猴每天接受溶剂（n= 6）或0.01（n= 8）、0.03（n= 8）或0.1（n= 5）mg ZK 137 316/kg体重，持续5个月经周期（C-1至C-5）。雌二醇、孕酮和促性腺激素曲线在涉及溶剂和0.01和0.03 mg ZK 137 316/kg体重的周期内均正常。在0.1 mg/kg组中，C-3和C-5中不存在周期中期雌二醇和促性腺激素激增以及随后的孕酮产生。在溶剂组和0.01 mg/kg组中，卵巢周期性伴随着及时月经。截至C-3，0.03 mg/kg组中一半动物和0.1 mg/kg组中所有动物均为闭经。在溶剂、0.01 mg/kg和0.03 mg/kg组中，在C-5的黄体中期观察到黄体。在0.1 mg/kg组中，大窦卵泡和囊性卵泡明显。因此，每日给予0.01 mg/kg ZK 136 317可使猕猴的月经周期正常。虽然每日给予0.03 mg/kg ZK 136 317可使卵巢周期性，但某些动物的月经中断。将剂量增加至0.1 mg。kg拮抗垂体功能，导致无排卵和闭经。长期低剂量的抗卵泡素ZK 137 316，它允许正常的卵巢/月经周期，有可能作为一种避孕药的妇女。[摘要自出版商]人类生殖的版权是牛津大学出版社/美国的财产，其内容不得复制或通过电子邮件发送到多个网站或张贴到一个listserv未经版权保持器的明确书面许可。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
Large doses of antiprogestin typically disrupt menstrual cyclicity. A chronic low-dose regimen of the potent new antiprogestin ZK 137 316, which permits continued menstrual cyclicity but alters gonadal-reproductive tract activity, was established. Rhesus monkeys received a vehicle (n= 6) or 0.01 (n= 8), 0.03 (n= 8) or 0.1 (n= 5) mg ZK 137 316/kg body weight daily for five menstrual cycles (C-1 to C-5). Oestradiol, progesterone and gonadotrophin profiles were normal during cycles involving vehicle and 0.01 and 0.03 mg ZK 137 316/kg body weight. In the 0.1 mg/kg group, mid-cycle oestradiol and gonadotrophin surges, and subsequent progesterone production, were absent in C-3 and C-5. Ovarian cyclicity was accompanied by timely menstruation in the vehicle and 0.01 mg/kg groups. By C-3, half the animals in the 0.03 mg/kg group and all animals in the 0.1 mg/kg group were amenorrhoeic. A corpus luteum was noted during the mid-luteal phase of C-5 in the vehicle, 0.01 mg/kg and 0.03 mg/kg groups. Large antral and cystic follicles were evident in the 0.1 mg/kg group. Thus, a daily treatment with 0.01 mg/kg ZK 136 317 permitted normal menstrual cyclicity in macaques. While the daily administration of 0.03 mg/kg ZK 136 317 allowed ovarian cyclicity, menstruation was disrupted in some animals. Increasing the dose to 0.1 mg./kg antagonized pituitary function and resulted in anovulation and amenorrhoea. A chronic low-dose regimen of the antiprogestin ZK 137 316, which permits normal ovarian/menstrual cyclicity, has potential as a contraceptive in women.[ABSTRACT FROM PUBLISHER]Copyright of Human Reproduction is the property of Oxford University Press/USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.