PUS, DEOXYRIBONUCLEIC-ACID, AND SPUTUM VISCOSITY
PUS, DEOXYRIBONUCLEIC-ACID, AND SPUTUM VISCOSITY
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DOI：
10.1136/thx.33.2.235
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发表时间：
1978-01-01
期刊：
影响因子：
10
通讯作者：
REID, L
中科院分区：
文献类型：
--
作者：
PICOT, R;DAS, I;REID, L
On 100 sputum specimens selected from patients suffering from chronic bronchitis, bronchiectasis, asthma, and cystic fibrosis total DNA content was related to macroscopic type, to total dry weight yield, and to the apparent viscosisty of the secretion at 1350 s-1 (shear rate): since DNA may be present, either as fibers or within cells, in 1/3 of the specimens the contribution of each form to the apparent viscosity was assessed. The effect on sputum viscosity of the addition of DNA in vitro was also studied. Whereas between mucoid, mucopurulent, and purulent macroscopic types a significant difference in total DNA and dry weight yield was found, viscosity was not significantly correlated with purulence. Similarly, the concentration of either cells or fibers correlated significantly with total DNA but not with viscosity. The in vitro addition of DNA to sputum caused a significant increase in its viscosity, and reasons for the differences between the in vivo and in vitro effect are discussed. Certain constituents of purulent sputum tend to increase viscosity and others to reduce it, and the influence of these varies in the several diseases studied.
