Timing of early activity in the visual cortex as revealed by simultaneous MEG and ERG recordings
Timing of early activity in the visual cortex as revealed by simultaneous MEG and ERG recordings
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DOI：
10.1016/j.neuroimage.2005.09.003
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发表时间：
2006-03-01
期刊：
影响因子：
5.7
通讯作者：
Kakigi, R
中科院分区：
文献类型：
--
作者：
Inui, K;Sannan, H;Kakigi, R
为了阐明视觉处理过程中最早的皮层活动的潜伏期，同时记录了6名人类受试者闪光刺激后的视网膜电图（ERG）和视觉诱发磁场（VEFs）。对右眼施加闪光刺激，并从放置在下眼睑上的皮肤电极记录ERG。所有受试者的ERG均显示两种主要偏转：眼睑负性约20 ms，阳性约60 ms，分别对应于a波和b波。VEFs最早成分（37 M）的平均起始和峰潜伏期分别为30.2和36.9 ms。α波潜伏期与37 M波起始潜伏期呈直线相关（r = 0.90，P = 0.011）。当对37 M进行单一等效电流偶极子分析时，6名受试者中有4名显示出高度可靠的结果。据估计，所有4名受试者的37 M发生器均位于纹状体皮质。由于预期视网膜中的后感受器活动在a波的峰值（20 ins）附近开始，因此比a波峰值晚10 ms出现的早期皮层活动被认为是闪光刺激后最早的皮层活动。(c)2005年爱思唯尔公司All rights reserved.
To clarify the latency of the earliest cortical activity in visual processing, electroretinograms (ERGs) and visual evoked magnetic fields (VEFs) following flash stimulation were recorded simultaneously in six human subjects. Flash stimuli were applied to the right eye and ERGs were recorded from a skin electrode placed on the lower lid. ERGs showed two major deflections in all subjects: an eyelid-negativity around 20 ms and a positivity around 60 ms corresponding to an a- and b-waves, respectively. The mean onset and peak latency of the earliest component of VEFs (37M) was 30.2 and 36.9 ms, respectively. There was a linear correlation between the peak latency of the a-wave and the onset latency of the 37M (r = 0.90, P = 0.011). When a single equivalent current dipole analysis was applied to the 37M, four out of six subjects showed highly reliable results. The generator of the 37M was estimated to be located in the striate cortex in all four subjects. Since postreceptoral activities in the retina are expected to start around the peak of the a-wave (20 ins), the early cortical activity, which appears 10 ms later than the a-wave peak, is considered to be the earliest cortical activity following flash stimulation. (c) 2005 Elsevier Inc. All rights reserved.