THE EFFECTS OF AGING ON NEURON NUMBER IN THE RAT SUPERIOR OLIVARY COMPLEX
THE EFFECTS OF AGING ON NEURON NUMBER IN THE RAT SUPERIOR OLIVARY COMPLEX
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DOI：
10.1016/0197-4580(90)90004-j
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发表时间：
1990-07-01
影响因子：
4.2
通讯作者：
CASEY, MA
中科院分区：
文献类型：
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作者：
CASEY, MA
上级橄榄复合体（SOC）是脑干中参与双耳信息处理的听觉中枢。定位声音的能力取决于SOC和其他听觉中心对双耳信号的有效处理。研究表明，老年大鼠的声音定位能力受损，SOC的形态学变化可能导致了这种缺陷。在本研究中，在年龄为3、12、24和30个月的Fischer 344大鼠组中，对SOC的三个关键核团进行神经元计数：斜方体内侧核（MNTB）、外侧上级橄榄核（LSO）和内侧上级橄榄核（MSO）。在LSO和MSO中，神经元数量在3至30月龄之间保持稳定，然而，在MNTB中，神经元数量在24和30月龄时显著减少。24月龄Fischer 344大鼠的MNTB中的神经元损失不像先前在24月龄Sprague-Dawley大鼠中报告的那样严重（8%损失与34%损失），表明SOC中的老化存在应变差异。
The superior olivary complex (SOC) is an auditory center in the brainstem involved in the processing of binaural information. The ability to localize sounds is dependent on the efficient processing of binaural signals by the SOC and other auditory centers. It has been demonstrated that sound localization ability is impaired in aged rats, and morphological changes in the SOC may contribute to this deficit. In the present study, neuron counts were done on three key nuclei of the SOC: the medial nucleus of the trapezoid body (MNTB), the lateral superior olivary nucleus (LSO), and the medial superior olivary nucleus (MSO) in groups of Fischer 344 rats aged 3, 12, 24, and 30 months. Neuron number remains stable between 3 and 30 months of age in the LSO and MSO, however, in the MNTB, neuron number is significantly reduced at 24 and 30 months of age. Neuron loss in the MNTB of 24-month-old Fischer 344 rats is not as heavy as that reported earlier in 24-month-old Sprague-Dawley rats (8% loss versus 34% loss), indicating a strain difference with regard to aging in the SOC.