Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils.
Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils.
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肿瘤源性 CXCL1 通过招募肿瘤相关中性粒细胞促进肺癌生长
DOI：
10.1155/2016/6530410
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发表时间：
2016
影响因子：
4.1
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Yuan M;Zhu H;Xu J;Zheng Y;Cao X;Liu Q
中性粒细胞在炎症过程中具有传统作用，并作为对抗感染的第一道防线。尽管它们对肿瘤发生和进展的贡献仍然存在争议，但最近积累的证据表明，肿瘤相关中性粒细胞（TANs）在癌症生物学的多个方面发挥着关键作用。在这里，我们检测到趋化因子CXCL 1显着升高，从3LL荷瘤小鼠的血清中。在体外，3LL细胞组成型表达和分泌较高水平的CXCL 1。此外，敲低3LL细胞中的CXCL 1表达通过抑制外周血中性粒细胞向肿瘤组织中的募集而显著阻碍肿瘤生长。此外，肿瘤浸润的中性粒细胞表达更高水平的MPO和Fas/FasL，这可能参与TAN介导的对CD 4+和CD 8 + T细胞的抑制。这些结果表明，肿瘤来源的CXCL 1有助于肺癌中的TAN浸润，这促进了肿瘤生长。
Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice. In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1. Furthermore, knocking down CXCL1 expression in 3LL cells significantly hindered tumor growth by inhibiting recruitment of neutrophils from peripheral blood into tumor tissues. Additionally, tumor-infiltrated neutrophils expressed higher levels of MPO and Fas/FasL, which may be involved in TAN-mediated inhibition of CD4+ and CD8+ T cells. These results demonstrate that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth.