Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.
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DOI：
10.1084/jem.192.9.1339
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发表时间：
2000-11-06
期刊：
影响因子：
--
通讯作者：
Kelsoe G
中科院分区：
文献类型：
--
作者：
Chen Z;Koralov SB;Kelsoe G
The complement system enhances antibody responses to T-dependent antigens, but paradoxically, deficiencies in C1 and C4 are strongly linked to autoantibody production in humans. In mice, disruption of the C1qa gene also results in spontaneous autoimmunity. Moreover, deficiencies in C4 or complement receptors 1 and 2 (CR1/CR2) lead to reduced selection against autoreactive B cells and impaired humoral responses. These observations suggest that C1 and C4 act through CR1/CR2 to enhance humoral immunity and somehow suppress autoimmunity. Here we report high titers of spontaneous antinuclear antibody (ANA) in C4 −/ − mice. This systemic lupus erythematosus–like autoimmunity is highly penetrant; by 10 mo of age, all C4 − /− females and most males produced ANA. In contrast, titers and frequencies of ANA in Cr2 − /− mice, which are deficient in CR1 and CR2, never rose significantly above those in normal controls. Glomerular deposition of immune complexes (ICs), glomerulonephritis, and splenomegaly were observed in C4 − /− but not Cr2 − /− mice. C4 − /−, but not Cr2 − /−, mice accumulate activated T and B cells. Clearance of circulating ICs is impaired in preautoimmune C4 − /−, but not Cr2 − /−, mice. C4 deficiency causes spontaneous, lupus-like autoimmunity through a mechanism that is independent of CR1/CR2.
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影响因子：
36.8
作者：
FIGUEROA, JE;DENSEN, P
通讯作者：
DENSEN, P
影响因子：
32.4
作者：
Hande, S;Notidis, E;Manser, T
通讯作者：
Manser, T
影响因子：
4.4
作者：
Chen, ZB;Koralov, SB;Kelsoe, G
通讯作者：
Kelsoe, G
影响因子：
--
作者：
Campbell, R D;Carroll, M C;Porter, R R
通讯作者：
Porter, R R
DOI：
10.1084/jem.191.3.435
发表时间：
2000-02-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Huang FP;Platt N;Wykes M;Major JR;Powell TJ;Jenkins CD;MacPherson GG
通讯作者：
MacPherson GG