Atrial natriuretic peptide expression in rats with different pulmonary hypertensive responses to hypoxia.
Atrial natriuretic peptide expression in rats with different pulmonary hypertensive responses to hypoxia.
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不同肺动脉高压对缺氧反应的大鼠心房钠尿肽的表达。
DOI：
10.1152/ajpheart.1997.273.1.h411
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hill,NS
中科院分区：
文献类型：
--
作者：
Klinger,JR;Wrenn,DS;Warburton,RR;Pietras,L;Ou,LC;Hill,NS
缺氧时心房利钠肽（ANP）表达的调节机制尚不清楚。我们假设，血浆免疫反应性心钠素（irANP）和右心irANP和ANP mRNA水平将更大的Sprague-Dawley大鼠发展更严重的缺氧性肺动脉高压（H大鼠）比另一个应变（M大鼠）。缺氧3周后H组大鼠右心室收缩压（RVSP）、右心室（RV）重量与左心室加室间隔（LV（+）S）重量的比值[RV/（LV+S）]均大于M组（分别为70 +/- 4 vs. 40 +/- 2 mmHg和0.59 +/- 0.02 vs. 0.50 +/- 0.02;两者P < 0.05），但两种大鼠品系的血浆ANP增加了2倍，RV irANP和ANP mRNA增加了5倍。M组大鼠恢复常氧3天后，RVSP、RV/（LV+S）、RV irANP和ANP mRNA水平均下降，H组则无明显变化。两种品系大鼠血浆irANP均降至基线水平。我们的结论是，除了右心室压力和肥大的变化，缺氧行为通过其他机制来调节右心室心钠素合成和循环心钠素水平在缺氧适应大鼠。
Mechanisms that regulate atrial natriuretic peptide (ANP) expression during hypoxia are not well defined. We hypothesized that plasma immunoreactive ANP (irANP) and right heart irANP and ANP mRNA levels would be greater in a strain of Sprague-Dawley rats that develops more severe hypoxic pulmonary hypertension (H rats) than another strain (M rats). After 3 wk of hypoxia (0.5 atm), right ventricular systolic pressure (RVSP) and the right ventricle (RV) weight-to-left ventricle plus septum (LV (+) S) weight ratio [RV/(LV+S)] were greater in H rats than in M rats (70 +/- 4 vs. 40 +/- 2 mmHg and 0.59 +/- 0.02 vs. 0.50 +/- 0.02, respectively; P < 0.05 for both), but plasma ANP increased twofold and RV irANP and ANP mRNA increased fivefold in both rat strains. After 3 days of normoxic recovery from chronic hypoxia, RVSP, RV/(LV+S), and RV irANP and ANP mRNA levels decreased in M rats but not in H rats. Plasma irANP decreased to baseline levels in both rat strains. We conclude that, in addition to changes in RV pressure and hypertrophy, hypoxia acts through other mechanisms to modulate RV ANP synthesis and circulating ANP levels in hypoxia-adapted rats.