Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development
Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development
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DOI：
10.1111/1467-8624.00433
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发表时间：
2002-05-01
影响因子：
4.6
通讯作者：
Webb, SJ
中科院分区：
文献类型：
--
作者：
Dawson, G;Carver, L;Webb, SJ
本研究利用脑电描记技术，探讨自闭症谱系障碍（ASD）幼儿是否存在面孔识别能力受损的问题。高密度脑事件相关电位（ERP）被记录到孩子的母亲的脸与一个不熟悉的女性的脸的照片和照片的最喜欢的与一个不熟悉的玩具从ASD儿童，儿童与典型的发展，和儿童与发展迟缓，所有3至4岁（N = 118）。发育正常的儿童对熟悉与不熟悉的面孔、熟悉与不熟悉的物体表现出P400和Nc两个成分的ERP幅度差异。相比之下，ASD儿童对熟悉和不熟悉的面孔的ERP没有表现出差异，但他们确实对熟悉和不熟悉的物体表现出P400和Nc振幅差异。发育迟缓儿童对面孔和物体的正慢波均表现出显着的ERP振幅差异。这些数据表明，自闭症与在生命早期表现出的面部识别障碍有关。
This study utilized electroencephalographic recordings to examine whether young children with autism spectrum disorder (ASD) have impaired face recognition ability. High-density brain event-related potentials (ERPs) were recorded to photos of the child's mother's face versus an unfamiliar female face and photos of a favorite versus an unfamiliar toy from children with ASD, children with typical development, and children with developmental delay, all 3 to 4 years of age (N = 118). Typically developing children showed ERP amplitude differences in two components, P400 and Nc, to a familiar versus an unfamiliar face, and to a familiar versus an unfamiliar object. In contrast, children with ASD failed to show differences in ERPs to a familiar versus an unfamiliar face, but they did show P400 and Nc amplitude differences to a familiar versus an unfamiliar object. Developmentally delayed children showed significant ERP amplitude differences for the positive slow wave for both faces and objects. These data suggest that autism is associated with face recognition impairment that is manifest early in life.