LAMINAR AND SPATIAL LOCALIZATION OF THE ISLANDS OF CALLEJA IN MICE
LAMINAR AND SPATIAL LOCALIZATION OF THE ISLANDS OF CALLEJA IN MICE
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DOI：
10.1016/j.neuroscience.2014.12.019
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发表时间：
2015-02-26
期刊：
影响因子：
3.3
通讯作者：
Wesson, D. W.
中科院分区：
文献类型：
--
作者：
Adjei, S.;Wesson, D. W.
Calleja岛(IC)是位于腹侧纹状体的密集细胞簇。IC在数量和定位上从动物到动物都是可变的，然而，这种差异的定量研究是不可用的。此外，目前尚不清楚IC是否占据小鼠嗅结节(OT)的特定区域，即拥有IC的腹侧纹状体结构。为了解决这些问题，我们检测了成年C57BL/6小鼠的IC。如前所述，我们发现IC的总数在大脑半球和小鼠之间有很大的差异。在OT的三个细胞层中均可见IC，但IC的大部分位于第III层。颈内动脉沿前-后轴和内侧-外侧轴的跨度不同。此外，在不同的动物中，IC在OT内的定位也不同。值得注意的是，在内侧OT观察到IC的概率大于在外侧观察到IC的概率。这些数据提供了关于小鼠IC的差异和相似之处的基本特征，并将为未来的活体研究提供信息，试图扰乱并可能记录IC。此外，我们预测IC中动物间的多样性可能是动物间行为差异的一种机制，特别是与奖励和动机相关的行为。(C)2014年IBRO。爱思唯尔有限公司出版。保留所有权利。
The islands of Calleja (IC) are dense clusters of cells localized within the ventral striatum. The IC have been described as variable in both number and localization from animal-to-animal, however, a quantitative investigation of this variability is unavailable. Further, it is presently unknown whether the IC occupy select areas of the olfactory tubercle (OT), the ventral striatum structure which possesses the IC in mice. To address these questions, we examined the IC of adult C57bl/6 mice. As previously noted, we found substantial inter-hemispheric and inter-mouse variations in the total number of IC. While the IC were observed in all three cell layers of the OT, the bulk of IC occupied layer iii. The span of the IC along the anterior-posterior and medial-lateral axes of the OT was variant. Further, localizations of the IC within the OT also differed across animals. Notably, the probability of observing an IC in the medial OT was greater than that of observing one in the lateral. These data provide a fundamental characterization of both differences and similarities regarding the IC in mice and will be informative for future in vivo studies seeking to perturb and possibly record from the IC. Further, we predict that inter-animal diversity in the IC may be a mechanism for inter-animal differences in behavior, especially reward-related and motivational behaviors. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.