Golgi division and membrane traffic
Golgi division and membrane traffic
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DOI：
10.1016/s0962-8924(97)01189-6
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发表时间：
1998-01-01
影响因子：
19
通讯作者：
Warren, G
中科院分区：
文献类型：
--
作者：
Lowe, M;Nakamura, N;Warren, G
高尔基复合体在哺乳动物细胞中具有独特的形态，包括位于细胞核附近的紧密并置的堆叠池的带状物，通常是中心粒。自世纪之交以来的观察已经揭示了细胞经历有丝分裂时高尔基体结构的戏剧性变化，并且最近的显微镜分析已经证实高尔基体带被转化为分散在整个有丝分裂细胞中的囊泡和小管簇。我们一直对这种分裂感兴趣，因为它为在分子水平上研究细胞器分裂提供了一个独特的机会。在这里，我们描述的方式，我们的理解已经通过另一个戏剧性的变化，有丝分裂中的膜功能，即膜交通的抑制。
The Golgi complex has a distinctive morphology in mammalian cells, comprising a ribbon of closely apposed stacked cisternae located adjacent to the nucleus and often the centrioles. Observations since the turn of the century have revealed dramatic changes in Golgi structure as cells undergo mitosis, and more recent microscopic analyses have confirmed that the Golgi ribbon is converted to clusters of vesicles and tubules dispersed throughout the mitotic cell. We have long been interested in this fragmentation since it offers a unique opportunity to study organelle division at the molecular level. Here, we describe the way in which our understanding has developed through another dramatic change to membrane function in mitosis, namely the inhibition of membrane traffic.