ABO Blood Group and Risk of Thromboembolic and Arterial Disease A Study of 1.5 Million Blood Donors
ABO Blood Group and Risk of Thromboembolic and Arterial Disease A Study of 1.5 Million Blood Donors
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DOI：
10.1161/circulationaha.115.017563
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发表时间：
2016-04-12
期刊：
影响因子：
37.8
通讯作者：
Edgren, Gustaf
中科院分区：
文献类型：
--
作者：
Vasan, Senthil K.;Rostgaard, Klaus;Edgren, Gustaf
背景- ABO血型与静脉血栓栓塞和动脉疾病的风险增加有关。然而，这种关联的报道幅度是不一致的，是基于证据的小规模study.Methods和结果-我们使用的SCANDAT 2（斯堪的纳维亚捐赠和输血）数据库的献血者与其他全国性的健康数据登记册调查ABO血型和第一次和复发性静脉血栓栓塞和动脉事件的发生率之间的关联。对1987年至2012年期间丹麦和瑞典的献血者进行了随访，以诊断血栓栓塞和动脉事件。泊松回归模型用于估计发病率比作为相对风险的措施。在1360万人-年的随访期间，共有9170例静脉和24653例动脉事件发生在1112072例患者中。与O型血相比，非O型血与静脉和动脉血栓栓塞事件的发生率较高相关。妊娠相关性静脉血栓栓塞发生率最高（发生率比，2.22; 95%置信区间，1.77-2.79），深静脉血栓形成（发生率比，1.92; 95%置信区间，1.80-2.05），和肺栓塞（发病率比，1.80; 95%置信区间，1.71-1.88）。结论-在这个健康的献血者群体中，非O血型解释了>30%的静脉血栓栓塞事件。虽然ABO血型可能与现有的预测系统一起用于识别风险个体，但其临床实用性需要与其他风险标志物进行进一步比较。
Background - ABO blood groups have been shown to be associated with increased risks of venous thromboembolic and arterial disease. However, the reported magnitude of this association is inconsistent and is based on evidence from small-scale studies.Methods and Results - We used the SCANDAT2 (Scandinavian Donations and Transfusions) database of blood donors linked with other nationwide health data registers to investigate the association between ABO blood groups and the incidence of first and recurrent venous thromboembolic and arterial events. Blood donors in Denmark and Sweden between 1987 and 2012 were followed up for diagnosis of thromboembolism and arterial events. Poisson regression models were used to estimate incidence rate ratios as measures of relative risk. A total of 9170 venous and 24 653 arterial events occurred in 1 112 072 individuals during 13.6 million person-years of follow-up. Compared with blood group O, non-O blood groups were associated with higher incidence of both venous and arterial thromboembolic events. The highest rate ratios were observed for pregnancy-related venous thromboembolism (incidence rate ratio, 2.22; 95% confidence interval, 1.77-2.79), deep vein thrombosis (incidence rate ratio, 1.92; 95% confidence interval, 1.80-2.05), and pulmonary embolism (incidence rate ratio, 1.80; 95% confidence interval, 1.71-1.88).Conclusions - In this healthy population of blood donors, non-O blood groups explain >30% of venous thromboembolic events. Although ABO blood groups may potentially be used with available prediction systems for identifying at-risk individuals, its clinical utility requires further comparison with other risk markers.