Exploring cancer genomic data from the cancer genome atlas project.
Exploring cancer genomic data from the cancer genome atlas project.
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DOI：
10.5483/bmbrep.2016.49.11.145
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发表时间：
2016-11
期刊：
影响因子：
3.8
通讯作者：
Lee JS
中科院分区：
文献类型：
--
作者：
Lee JS
癌症基因组图谱(TCGA)汇编了来自33种癌症的10,000多个样本的基因组、表观基因组和蛋白质组数据，旨在提高我们对癌症发展的分子基础的理解。这些全基因组信息的可获得性为发现信号通路的新的关键调节因子或预先存在的成员在通路中的新角色提供了前所未有的机会。为了利用这一进展，有必要学习系统的方法，以帮助发现反映遗传变化、预后或治疗反应的新基因。这篇小评介绍了TCGA项目的最新情况，并解释了如何使用TCGA数据。
The Cancer Genome Atlas (TCGA) has compiled genomic, epigenomic, and proteomic data from more than 10,000 samples derived from 33 types of cancer, aiming to improve our understanding of the molecular basis of cancer development. Availability of these genome-wide information provides an unprecedented opportunity for uncovering new key regulators of signaling pathways or new roles of pre-existing members in pathways. To take advantage of the advancement, it will be necessary to learn systematic approaches that can help to uncover novel genes reflecting genetic alterations, prognosis, or response to treatments. This minireview describes the updated status of TCGA project and explains how to use TCGA data.