Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
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DOI：
10.1097/00002030-200403050-00005
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发表时间：
2004-03-05
期刊：
影响因子：
3.8
通讯作者：
Overbaugh, J
中科院分区：
文献类型：
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作者：
Sagar, M;Lavreys, L;Overbaugh, J
工作背景：我们以前的研究表明，大多数非洲妇女感染了多种HIV-1基因变异，而在其余妇女中，在感染早期仅检测到单一病毒基因型。与多种病毒变异体的感染与较高的血浆HIV-1 RNA水平和更快的CD 4 T细胞decline.Method：社会行为特征，使用激素避孕药，性传播疾病的存在进行了前瞻性评估，大约每月的时间间隔艾滋病毒-1收购在肯尼亚的女性性工作者。我们评估了这些因素和HIV-1的遗传复杂性早期infection.Results：一百和五十六妇女被列入本分析，其中89人有多个病毒基因型和67个有一个单一的基因型在原发感染之间的关系。与携带单一变异体的女性相比，携带多种变异体的女性更容易发生生殖道感染[比值比（OR），4.7; 95%置信区间（CI），1.4-18.1]或在感染时使用激素避孕药（OR，2.7; 95% CI，1.3-5.6）。在多变量分析中，这些因素是独立的预测早期HIV-1的遗传复杂性，并在感染早期的多个病毒变异的存在下仍然显着相关的一个较高的稳态血浆HIV-1 RNA level.Conclusion：生殖道感染和激素避孕药的使用在传输的时间的存在与收购的多个HIV-1变异。(C)2004年利平科夫特威廉姆斯威尔金斯。
Background: Our previous studies have shown that the majority of African women were infected with multiple HIV-1 genetic variants, while in the remaining women only a single viral genotype was detected early in infection. Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline.Method: Socio-behavioral characteristics, use of hormonal contraceptives, and the presence of sexually transmitted diseases were prospectively assessed at approximately monthly intervals around the time of HIV-1 acquisition in female sex workers in Kenya. We assessed the relationship between these factors and HIV-1 genetic complexity early in infection.Results: One hundred and fifty-six women were included in this analysis, of whom 89 had multiple viral genotypes and 67 had a single genotype at primary infection. Women with multiple variants were more likely to have a genital tract infection [odds ratio (OR), 4.7; 95% confidence interval (Cl), 1.4-18.1] or to be using hormonal contraceptives (OR, 2.7; 95% Cl, 1.3-5.6) at the time of their infection than those with a single variant. In multivariate analyses, these factors were independent predictors of early HIV-1 genetic complexity, and the presence of multiple viral variants early in infection remained significantly associated with a higher steady state plasma HIV-1 RNA level.Conclusion: The presence of genital tract infections and hormonal contraceptive use at the time of transmission were associated with the acquisition of multiple HIV-1 variants. (C) 2004 Lippincoft Williams Wilkins.