Stress-induced activation of receptor signaling by protease-mediated cleavage.
Stress-induced activation of receptor signaling by protease-mediated cleavage.
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DOI：
10.1042/bcj20200941
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发表时间：
2021-05-28
影响因子：
4.1
通讯作者：
He, Ping
中科院分区：
文献类型：
--
作者：
Hou, Shuguo;Zhang, Jie;He, Ping
植物编码大量蛋白酶，通过蛋白水解切割各种蛋白质底物来激活细胞内信号传导。一种类型的底物是前配体，包括肽激素，其被细胞表面驻留受体感知。肽激素通常首先合成为前肽，然后被特定的蛋白酶裂解以活化。越来越多的证据表明，蛋白酶介导的前配体的切割可以被环境胁迫触发，并随后激活植物胁迫信号。在这个角度来看，我们强调了几个最近的出版物，并提供了一个最新的压力诱导的裂解前肽和受体相关的组分蛋白酶在激活细胞表面驻留受体信号在植物中。最后讨论了蛋白酶在植物逆境响应中功能研究中存在的问题和未来的挑战。
Plants encode a large number of proteases in activating intracellular signaling through proteolytic cleavages of various protein substrates. One type of the substrates is proligands, including peptide hormones, which are perceived by cell surface-resident receptors. The peptide hormones are usually first synthesized as propeptides, and then cleaved by specific proteases for activation. Accumulating evidence indicates that the protease-mediated cleavage of proligands can be triggered by environmental stresses and subsequently activates plant stress signaling. In this perspective, we highlight several recent publications and provide an update about stress-induced cleavage of propeptides and receptor-associated components by proteases in the activation of cell surface-resident receptor signaling in plants. We also discuss some questions and future challenges in the research of protease functions in plant stress response.