Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors.
Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors.
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DOI：
10.3389/fimmu.2020.594609
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发表时间：
2020
影响因子：
7.3
通讯作者：
Jiang P
中科院分区：
文献类型：
--
作者：
Zhang Y;Guan XY;Jiang P
The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell exclusion mechanisms to resist immunotherapy. T cells have to go through three steps to fight against tumors: trafficking to the tumor core, surviving and expanding, and maintaining the memory phenotype for long-lasting responses. Cytokines and chemokines play critical roles in modulating the recruitment of T cells and the overall cellular compositions of the tumor microenvironment. Manipulating the cytokine or chemokine environment has brought success in preclinical models and early-stage clinical trials. However, depending on the immune context, the same cytokine or chemokine signals may exhibit either antitumor or protumor activities and induce unwanted side effects. Therefore, a comprehensive understanding of the cytokine and chemokine signals is the premise of overcoming T-cell exclusion for effective and innovative anti-cancer therapies.
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影响因子：
11.2
作者：
Chang, Li-Yuan;Lin, Yung-Chang;Lin, Chun-Yen
通讯作者：
Lin, Chun-Yen
影响因子：
5.8
作者：
Arenberg, DA;White, ES;Strieter, RM
通讯作者：
Strieter, RM
DOI：
10.1111/j.1749-6632.2009.05160.x
发表时间：
2009-01-01
期刊：
CYTOKINE THERAPIES: NOVEL APPROACHES FOR CLINICAL INDICATIONS
影响因子：
--
作者：
Chavez, Antonio Romo de Vivar;Buchser, William;Lotze, Michael T.
通讯作者：
Lotze, Michael T.
影响因子：
11.5
作者：
Alfaro, Carlos;Teijeira, Alvaro;Melero, Ignacio
通讯作者：
Melero, Ignacio
影响因子：
4.7
作者：
Bellone M;Calcinotto A
通讯作者：
Calcinotto A