Lobular endocervical glandular hyperplasia represents pyloric gland metaplasia?
Lobular endocervical glandular hyperplasia represents pyloric gland metaplasia?
复制标题
小叶宫颈管腺体增生代表幽门腺化生？
DOI：
10.1097/00000478-200002000-00042
复制
发表时间：
2000
影响因子：
5.6
通讯作者：
T. Manabe
中科院分区：
文献类型：
--
作者：
Y. Mikami;T. Manabe
我们怀着极大的兴趣阅读了努奇等人写的文章。5小叶性颈内腺增生症(LEGH)。他们报告了13例LEGH，并与14例腺瘤、恶性肿瘤和其他假性肿瘤性腺病进行了比较。根据Nucci等人的说法，Legh由小到中等大小的圆形腺体组成，通常以较大的中央腺体为中心。腺体之间由宫颈间质隔开，排列着柱状粘液细胞，与正常宫颈内膜相似，没有明显的细胞学异型性。我们最近报道了10例恶性腺瘤的组织学分析，采用了一系列组织化学染色，包括用于表征上皮粘液的组织化学染色。1、2我们将相互关联的病变分为三类：典型腺瘤恶性病变、胃化生和显性腺癌。这三种类型的病变在大多数病例中并存。它们的共同特征是表达胃表型，特别是幽门粘膜的表型，包括粘蛋白、胃蛋白酶原和内分泌细胞。一种新的针对胃腺粘液细胞的单抗HIK1083是识别这些病变的有用工具。
With great interest, we read the article written by Nucci et al. 5 concerning lobular endocervical glandular hyperplasia (LEGH). They reported 13 cases of LEGH and compared them with 14 cases of adenoma malignum and other pseudoneoplastic glandular lesions. According to Nucci et al., LEGH consists of small to moderately sized rounded glands often centered around a larger central gland. The glands were separated from each other by cervical stroma and were lined by columnar mucinous cells similar to the normal endocervix, which showed no significant cytologic atypia.We recently reported a histologic analysis of 10 cases of adenoma malignum using a battery of histochemical stains, including those used for characterizing epithelial mucins. 1, 2 We classified three types of lesions that were related to each other: typical adenoma malignum lesion, gastric metaplasia, and overt adenocarcinoma. These three types of lesions coexisted in most cases. Their common feature was an expression of gastric phenotypes, especially those of the pyloric mucosa, including mucins, pepsinogen, and endocrine cells. A new monoclonal antibody, HIK1083, which is specific for gastric gland mucous cells, 4 is a useful tool in the recognition of these lesions.