Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
Increased risk of A(H1N1)pdm09 influenza infection in UK pig industry workers compared to a general population cohort.
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与普通人群相比，英国猪行业工人的A（H1N1）PDM09流感感染的风险增加。
DOI：
10.1111/irv.12364
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发表时间：
2016-07
影响因子：
4.4
通讯作者：
Combating Swine Influenza (COSI) Consortium
中科院分区：
文献类型：
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作者：
Fragaszy E;Ishola DA;Brown IH;Enstone J;Nguyen-Van-Tam JS;Simons R;Tucker AW;Wieland B;Williamson SM;Hayward AC;Flu Watch Group;Wood JL;Combating Swine Influenza (COSI) Consortium
猪是流感病毒重组的混合容器，但猪和人之间的流感传播程度尚不清楚。评估猪的职业暴露是否是人类感染人和猪适应性流感病毒的风险因素。 将英国养猪业工人的年龄、地区、采样月份和性别与来自流感观察研究的基于社区的对照组进行频率匹配。HI测定定量猪和人A（H1）和A（H3）流感病毒的抗体（滴度≥ 40被认为是血清阳性，表明感染）。使用针对疫苗接种调整的多变量回归模型，检查血清阳性与职业猪暴露之间的病毒特异性相关性。还对同一农场的猪进行了血清阳性检测。42%的猪对A（H1N1）pdm 09呈血清阳性。与对照组相比，养猪业工作人员显示A（H1N1）pdm 09血清阳性的几率增加，尽管置信区间（CI）较宽，考虑与其他猪A（H1）病毒可能的交叉反应性后调整的比值比（aOR）为25·3，95% CI（1·4-536·3），P = 0·028。结果表明，A（H1N1）pdm 09病毒在英国猪流行期间和随后的人类A（H1N1）pdm 09循环期间是常见的，猪职业暴露是人类感染的危险因素。对养猪业工人进行流感免疫接种可能会减少传播和病毒重组的可能性。
Pigs are mixing vessels for influenza viral reassortment, but the extent of influenza transmission between swine and humans is not well understood. To assess whether occupational exposure to pigs is a risk factor for human infection with human and swine‐adapted influenza viruses. UK pig industry workers were frequency‐matched on age, region, sampling month, and gender with a community‐based comparison group from the Flu Watch study. HI assays quantified antibodies for swine and human A(H1) and A(H3) influenza viruses (titres ≥ 40 considered seropositive and indicative of infection). Virus‐specific associations between seropositivity and occupational pig exposure were examined using multivariable regression models adjusted for vaccination. Pigs on the same farms were also tested for seropositivity. Forty‐two percent of pigs were seropositive to A(H1N1)pdm09. Pig industry workers showed evidence of increased odds of A(H1N1)pdm09 seropositivity compared to the comparison group, albeit with wide confidence intervals (CIs), adjusted odds ratio after accounting for possible cross‐reactivity with other swine A(H1) viruses (aOR) 25·3, 95% CI (1·4–536·3), P = 0·028. The results indicate that A(H1N1)pdm09 virus was common in UK pigs during the pandemic and subsequent period of human A(H1N1)pdm09 circulation, and occupational exposure to pigs was a risk factor for human infection. Influenza immunisation of pig industry workers may reduce transmission and the potential for virus reassortment.