OCCUPATIONAL EXPOSURE MONITORING USING BREATH ANALYSIS
OCCUPATIONAL EXPOSURE MONITORING USING BREATH ANALYSIS
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DOI：
10.1097/00043764-198608000-00014
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发表时间：
1986-08-01
影响因子：
3.2
通讯作者：
GUILLEMIN, MP
中科院分区：
文献类型：
--
作者：
DROZ, PO;GUILLEMIN, MP
呼吸分析已在许多场合被提议用于监测溶剂暴露。然而，由于（1）方法本身（取样和分析）的困难和（2）缺乏关于其与照射剂量关系的数据，它仍然很少被常规使用。本文简要回顾、比较和讨论了目前可用的各种方法。重点是同时使用CO_2作为呼吸指数。使用这种方法的两种方法。呼吸分析职业暴露监测的优点和局限性进行了讨论，使用实验，现场和模拟研究中获得的数据。苯、甲苯、苯乙烯、1，1，1-三氯乙烯和四氯乙烯被作为表现出各种毒代动力学特性的溶剂的例子。最后，将呼吸分析与其他生物监测方法进行了比较。
Breath analysis has been proposed on numerous occasions for monitoring solvent exposure. Nevertheless, it is still rarely used routinely because of (1) difficulties in the methodology itself (sampling and analysis) and (2) lack of data concerning its relationship to exposure dose. The various methods available today are briefly reviewed, compared, and discussed. Emphasis is on the simultaneous use of CO₂ as a respiratory index. Two methods using this approach are presented. The advantages and limitations of breath analysis for occupational exposure monitoring are discussed using data obtained in experimental, field, and simulation studies. Benzene toluene, styrene, 1,1,1-trichloroethylene, and tetrachloroethylene are taken as examples of solvents showing various toxicokinetic properties. Finally, breath analysis is compared with other biological monitoring methods.