Age Dependence of the Levels of Plasma Norepinephrine, Aldosterone, Renin Activity and Urinary Vanillylmandelic Acid in Normal and Essential Hypertensives
Age Dependence of the Levels of Plasma Norepinephrine, Aldosterone, Renin Activity and Urinary Vanillylmandelic Acid in Normal and Essential Hypertensives
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DOI：
10.4067/s0716-97602004000100010
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发表时间：
2004-01-01
影响因子：
6.7
通讯作者：
HAMMAD, SOMAYA A
中科院分区：
文献类型：
--
作者：
ABD-ALLAH, NADIA M;HASSAN, FAYEZA H;HAMMAD, SOMAYA A
在本研究中，静息血浆去甲肾上腺素，肾上腺素，血清醛固酮的参考上限（URL）。确定了年龄范围（5-60岁）的健康埃及正常血压受试者的血浆肾素活性、醛固酮/肾素活性比以及尿香草基扁桃酸。血浆去甲肾上腺素、UVMA、血清醛固酮和PRA存在显著的年龄效应，而血浆肾上腺素水平的单一URL是令人满意的。在无并发症的未经治疗的原发性高血压受试者（5-60岁）中。血浆去甲肾上腺素、肾上腺素和尿香草扁桃酸高于相应URLs的平均发生率分别为85.10%、62.15%和83.20%。这表明，血浆儿茶酚胺浓度的升高更可能是一个共同的结果，而不是发挥可能的作用，在高血压的发病机制，支持血浆儿茶酚胺水平之间的相关系数不显著的收缩压和舒张压值（SBP和DBP）在所有高血压年龄组。原发性醛固酮增多症中未检测到正常血钾的原发性高血压患者在任何年龄使用醛固酮/血浆肾素活性比值作为一个主要的筛选方法。本文报告了7个高血压儿童和青少年的收缩压或舒张压与UVMA水平、老年高血压患者的血清醛固酮的相关系数。和PRA的变化。
In the present study the upper reference limits (URLs) for resting plasma norepinephrine, epinephrine, serum aldosterone. plasma renin activity, aldosterone/ renin activity ratio, its well as Urinary vanillylmandelic acid in healthy Egyptian normotensive subjects over a range of ages (5-60 yr) were established. There was a significant age effect on plasma norepinephrine, UVMA, serum aldosterone and PRA, whereas a single URL for plasma epinephrine level is satisfactory. In uncomplicated untreated essential hypertensive subjects (5-60 yr). the average prevalence of elevation in the plasma norepinephrine, epinephrine and urinary vanillylmandelic acid above their corresponding URLs was 85.10,62.15 and 83.20 %, respectively. This suggests that elevation in plasma catecholamine concentrations is more likely a common consequence than playing a possible role in the pathogenesis of hypertension, supported by insignificant correlation coefficients between the plasma catecholamine levels and resting systolic and diastolic blood pressure values (SBP&DBP) in all hypertensive age groups. Primary hyperaldosteronism was not detected among the normokalemic essential hypertensives at any age using aldosterone /plasma renin activity ratio as a primary screening method. In the present Study, 7 statistically significant positive coefficient correlations are reported for SBP or DBP values with UVMA levels in hypertensive children and adolescents, serum aldosterone in old hypertensives. and PRA in adult hypertensives.