Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.
Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.
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DOI：
10.1042/bst20160069
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发表时间：
2016-08-15
影响因子：
3.9
通讯作者：
Hong CC
中科院分区：
文献类型：
--
作者：
Jiramongkolchai P;Owens P;Hong CC
骨形态发生蛋白（BMPs）属于转化生长因子-β（TGF-β）家族信号通路。与TGF-β类似，BMP在发育和疾病中的复杂作用通过其在各种癌症和癌症阶段中的二分作用来证明。虽然早期的研究涉及BMP信号在肿瘤抑制表型，最近的实验结果认为BMP作为有效的肿瘤促进剂。通过了解BMP在独特的癌症细胞类型中的背景作用及其周围肿瘤微环境的影响，这些复杂性中的许多正在变得更加清晰。在这里，我们回顾了BMP信号在癌症中的新作用，重点是BMP信号在个体癌症中作为有效的治疗靶点的分子基础。
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent tumour promoters. Many of these complexities are becoming illuminated by understanding the role of BMPs in their contextual role in unique cell types of cancer and the impact of their surrounding tumour microenvironment. Here we review the emerging roles of BMP signalling in cancer, with a focus on the molecular underpinnings of BMP signalling in individual cancers as a valid therapeutic target for cancer prevention and treatment.