Transient cochlear ischemia and its effects on the stria vascularis
Transient cochlear ischemia and its effects on the stria vascularis
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DOI：
10.1097/00001756-200505310-00004
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发表时间：
2005-05-31
期刊：
影响因子：
1.7
通讯作者：
Gyo, K
中科院分区：
文献类型：
--
作者：
Morizane, I;Hakuba, N;Gyo, K
观察了短暂性耳蜗缺血对耳蜗血管纹的影响。15分钟的缺血使耳蜗内电位在第1天降低了175 mV;在第7天恢复正常Na+，K+-ATP酶（Na+/K+-泵的标记物）和连接蛋白26（间隙连接的标记物）的免疫染色在第1天和第4天受到抑制，电子显微镜显示细胞间隙扩大，血管纹中有大量空泡形成。到第7天，这些形态学变化完全消失。结果表明，短暂性缺血导致血管纹可逆的功能障碍，并伴有细微的结构变化，这可能是由于Na+/K+泵或间隙连接功能障碍造成的。NeuroReport 16：799-802（c）2005 Lippincott威廉姆斯和威尔金斯。
The effects of transient cochlear ischemia on the stria vascularis were studied. Fifteen minutes of ischemia decreased the endocochlear potential by up to 175 mV on day 1; it returned to normal on day 7 Immunostaining for Na+,K+-ATPase, a marker for the Na+/K+-pump, and for connexin 26, a marker for gap junctions, was inhibited on days I and 4, and returned to normal on day 7 Electron microscopy showed expansion of the intercellular space with abundant vacuolar formation in the stria vascularis. These morphological changes disappeared completely by day 7 The results indicate that transient ischemia causes a reversible functional disorder of the stria vascularis with fine structural changes, which may be owing to dysfunction of Na+/K+-pump or gap junctions. NeuroReport 16:799-802 (c) 2005 Lippincott Williams & Wilkins.