More peptides and other diverse constituents of the marine mollusk Philinopsis speciosa
More peptides and other diverse constituents of the marine mollusk Philinopsis speciosa
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DOI：
10.1021/jo9719867
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发表时间：
1998-05-15
影响因子：
3.6
通讯作者：
Scheuer, PJ
中科院分区：
文献类型：
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作者：
Nakao, Y;Yoshida, WY;Scheuer, PJ
除了五种与kullycin-1相关的新缩肽（1），对软体动物Philinopsis speciosa的进一步研究还产生了一种线性肽pupukeamide（14）和一种前所未有的大环内酯tolytoxin-23-acetate（7）。化学组成表明，这些化合物来源于蓝绿藻，并通过草食性软体动物传播到P，speciosa。这可以通过实验室实验来验证。主要通过光谱技术和通过水解肽然后通过手性色谱法的立体化学来确定结构。
In addition to five new depsipeptides related to kulolide-1 (1), further examination of the mollusk Philinopsis speciosa has yielded a linear peptide, pupukeamide (14), and an unprecedented macrolide, tolytoxin-23-acetate (7). Chemical makeup suggested that the compounds originate from blue-green algae and are transmitted via herbivorous mollusks to P, speciosa. This could be verified by laboratory experiment. The structures were determined largely by spectroscopic techniques and the stereochemistry by hydrolysis of the peptides followed by chiral chromatography.