Depression in Patients with Coronary Heart Disease
Depression in Patients with Coronary Heart Disease
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DOI：
10.1016/j.amjmed.2008.09.010
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发表时间：
2008-11-01
影响因子：
5.9
通讯作者：
Freedland, Kenneth E.
中科院分区：
文献类型：
--
作者：
Carney, Robert M.;Freedland, Kenneth E.
在冠心病（CHD）病程的任何特定阶段，约20%的患者患有重度抑郁症，20%患有轻度抑郁症。抑郁症会导致严重的心理和社会病态，并且是进一步心脏发病和死亡的一个风险因素。尽管存在许多可能的生物学和行为学机制，但抑郁症增加心脏事件和死亡风险的因果途径尚未得到很好的理解。尽管抑郁症会导致病态，并且对冠心病患者的生活质量具有毁灭性影响，但它常常被漏诊且未得到治疗。本文介绍了在初级医疗和心脏病学环境中使用的筛查技术，并讨论了对冠心病患者抑郁症现有治疗方法的安全性和有效性。（C）2008爱思唯尔公司。保留所有权利。《美国医学杂志》（2008年）121卷，S20 - S27页
Approximately 20% of patients with coronary heart disease (CHD) have major depression and 20% have minor depression at any given point in the course of their illness. Depression causes significant psychological and social morbidity, and is a risk factor for further cardiac morbidity and mortality. Although there are many possible biological and behavioral mechanisms, the causal pathways through which depression increases the risk for cardiac events and death are not well understood. Despite the morbidity associated with depression, and the devastating impact it has on the quality of life of patients with CHD, it is underdiagnosed and often left untreated. This article describes screening techniques for use in primary care and cardiology settings, and discusses the safety and efficacy of available treatments for depression in patients with CHD. (C) 2008 Elsevier Inc. All rights reserved. The American Journal of Medicine (2008) 121, S20-S27