Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: Applications in the study of human trabecular bone microarchitecture
Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: Applications in the study of human trabecular bone microarchitecture
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DOI：
10.1016/j.bone.2007.11.018
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发表时间：
2008-04-01
期刊：
影响因子：
4.1
通讯作者：
Hans, Didier
中科院分区：
文献类型：
--
作者：
Pothuaud, Laurent;Carceller, Pascal;Hans, Didier
X射线成像仍然是一种非常具有成本效益的技术，在医学和材料科学中有许多应用。然而，X射线成像的物理过程将被研究的对象或组织的3维（3D）微架构变换（例如，投影）成复杂的2D灰度级纹理。3D/2D投影过程仍然是一个困难的数学问题，无论是演示还是建立良好的相关性都没有将基于2D纹理分析的测量定位为3D微结构的有效间接评估。骨小梁评分（TBS）是一种新的灰度纹理测量方法，它利用2D投影图像的实验变异函数。本研究的目的是确定使用mu CT重建评估的松质骨微结构的3D特征与使用直接来自3D mu CT重建的2D投影图像评估的TBS之间的相关性水平。使用来自不同解剖部位（腰椎、股骨颈和桡骨远端）的人尸体骨样本集进行分析。通过标准多元回归分析和使用通用数学3D/2D关系建立了显著相关性。在这两种情况下，相关性建立了TBS和骨微结构的两个3D特征之间的显着关系：骨体积分数和平均骨厚度。特别是，TBS似乎可以准确区分两种3D微结构，这两种微结构表现出相同的骨量，但具有不同的骨小梁特征。这些结果表明存在一个强大的和通用的关系，考虑到简化模型的二维投影图像。最终，这可能导致直接在常规临床实践中获得的DXA图像上使用TBS测量。(c)2007年爱思唯尔公司All rights reserved.
X-ray imaging remains a very cost-effective technique, with many applications in both medical and material science. However, the physical process of X-ray imaging transforms (e.g. projects) the 3-dimensional (3D) microarchitecture of the object or tissue being studied into a complex 2D grey-level texture. The 3D/2D projection process continues to be a difficult mathematical problem, and neither demonstrations nor well-established correlations have positioned 2D texture analysis-based measurement as a valid indirect evaluation of 3D microarchitecture. The trabecular bone score (TBS) is a new grey-level texture measurement which utilizes experimental variograms of 2D projection images. The aim of the present study was to determine the level of correlation between the 3D characteristics of trabecular bone microarchitecture, as evaluated using mu CT reconstruction, and TBS, as evaluated using 2D projection images derived directly from 3D mu CT reconstruction. Analyses were performed using sets of human cadaver bone samples from different anatomical sites (lumbar spine, femoral neck, and distal radius). Significant correlations were established via standard multiple regression analysis, and via the use of a generic mathematical 3D/2D relationship. In both instances, the correlations established a significant relationship between TBS and two 3D characteristics of bone microarchitecture: bone volume fraction and mean bone thickness. In particular, it appears that TBS permits to accurately differentiate between two 3D microarchitectures that exhibit the same amount of bone, but different trabecular characteristics. These results demonstrate the existence of a robust and generic relationship, taking into consideration a simplified model of a 2D projection image. Ultimately, this may lead to using TBS measurements directly on DXA images obtained in routine clinical practice. (c) 2007 Elsevier Inc. All rights reserved.