Ascertaining Subjective Cognitive Decline: A Comparison of Approaches and Evidence for Using an Age-Anchored Reference Group.
Ascertaining Subjective Cognitive Decline: A Comparison of Approaches and Evidence for Using an Age-Anchored Reference Group.
复制标题
确定主观认知能力下降：使用年龄锚定参考组的方法和证据的比较。
DOI：
10.3233/jad-150251
复制
发表时间：
2015-09-24
期刊：
影响因子：
--
通讯作者：
Cosentino S
中科院分区：
文献类型：
--
作者：
Tandetnik C;Farrell MT;Cary MS;Cines S;Emrani S;Karlawish J;Cosentino S
主观认知下降（SCD）越来越被认为有希望检测临床前阿尔茨海默病。如何确定SCD对于确定其在识别风险个体中的潜在效用至关重要，然而SCD措施在沿着几个维度上不同。我们的目的是研究在何种程度上报告SCD的健康老年人（HE）可能会受到影响的SCD措施的特点。我们调查了不同措施中SCD认可率的变化，包括一个开放式问题。我们还研究了跨措施的反应的关联，以及特定SCD项目与客观记忆表现的相关程度。99名HE完成了一系列问卷，从中提取了10个项目，用于检查SCD的记忆和认知的其他方面。我们应用Cochran's Q检验来评估SCD率的差异，相关分析来检查SCD反应的关联，回归模型来确定SCD项目和延迟言语记忆之间的关联。SCD的发生率随评估形式的变化而变化，记忆力为1 - 7%，注意力为5 - 20%。SCD是较低的内存与非内存域。SCD项目在域内和域间均相关。与同龄人相比，记忆相关的SCD是记忆最准确的预测因子。SCD项目的特征影响赞同率。使用“年龄锚定”问题查询SCD可能最准确地反映实际认知表现。
Subjective Cognitive Decline (SCD) is increasingly considered promising to detect preclinical Alzheimer’s disease. How SCD is ascertained is critical for determining its potential utility in identifying at-risk individuals, yet SCD measures differ along several dimensions. We aimed to examine the extent to which reports of SCD in healthy elders (HE) may be influenced by the characteristics of the SCD measures. We investigated variations in rates of SCD endorsement across different measures, including an open-ended question. We also examined the association of responses across measures, and the degree to which specific SCD items were associated with objective memory performance. 99 HE completed a series of questionnaires from which 10 items examining SCD for memory and other aspects of cognition were drawn. We applied Cochran’s Q tests to assess differences in rates of SCD, correlation analyses to examine association of SCD responses and regression models to determine the association between SCD items and delayed verbal memory. Rates of SCD varied as a function of the assessment format, ranging from 1 to 7 % for memory and 5 to 20% for concentration. SCD was lower for memory versus non-memory domains. SCD items were associated both within and across domains. The most accurate predictor of memory was memory-related SCD in comparison to others the same age. Characteristics of SCD items influence rates of endorsement. Querying SCD using an “age-anchored” question may provide the most accurate reflection of actual cognitive performance.