Phthalates: Toxicogenomics and inferred human diseases
Phthalates: Toxicogenomics and inferred human diseases
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DOI：
10.1016/j.ygeno.2010.11.008
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发表时间：
2011-03-01
期刊：
影响因子：
4.4
通讯作者：
Li, Steven Shoei-Lung
中科院分区：
文献类型：
--
作者：
Singh, Sher;Li, Steven Shoei-Lung
邻苯二甲酸盐被广泛用作增塑剂，以软化和增加聚氯乙烯塑料的柔韧性，但它们会渗入周围环境。有足够的证据表明，接触邻苯二甲酸盐会导致啮齿动物的发育和生殖毒性。从比较毒物基因组学数据库（CTD）中获得16种邻苯二甲酸酯与基因/蛋白质的相互作用，发现5种最常被整理的邻苯二甲酸酯（DEHP/MEHP和DBP/BBP/MBP）与249种独特的基因/蛋白质之间共有445种相互作用。对这249个独特基因/蛋白的基因本体、通路和网络进行了全面分析。结果发现，前34个基因/蛋白的通路和网络与249个独特基因/蛋白的通路和网络非常相似。因此，前34个基因/蛋白可作为邻苯二甲酸盐毒性的分子生物标志物。邻苯二甲酸盐毒性排名前三位的是心脏毒性、肝毒性和肾毒性，排名前20位的疾病包括心血管、肝脏、泌尿、内分泌和生殖器疾病。(C) 2010爱思唯尔公司版权所有。
Phthalates are widely used as plasticizers to soften and increase the flexibility in polyvinyl chloride plastics, but they can leach into the surrounding environment. There is sufficient evidence in rodents that phthalate exposure causes developmental and reproductive toxicity.The curated interactions between 16 phthalates and genes/proteins were obtained from Comparative Toxicogenomics Database (CTD), and a total of 445 interactions between the five most frequently curated phthalates (DEHP/MEHP and DBP/BBP/MBP) and 249 unique genes/proteins were found. The GeneOntology, pathways and networks of these 249 unique genes/proteins were fully analyzed. The pathways and networks of top 34 genes/proteins were found to be very similar to those of the 249 unique genes/proteins. Thus, the top 34 genes/proteins may serve as molecular biomarkers of phthalate toxicity.The top three phthalate toxicity categories were found to be cardiotoxicity, hepatotoxicity and nephrotoxicity, and the top 20 diseases included cardiovascular, liver, urologic, endocrine and genital diseases. (C) 2010 Elsevier Inc. All rights reserved.