A case of lung tuberculosis in a patient with rheumatoid arthritis treated with infliximab after antituberculosis chemoprophylaxis with isoniazid
A case of lung tuberculosis in a patient with rheumatoid arthritis treated with infliximab after antituberculosis chemoprophylaxis with isoniazid
复制标题
类风湿性关节炎患者异烟肼抗结核化学预防后英夫利昔单抗治疗并发肺结核一例
作者：
Y. Hirano;T. Kojima;Y. Kanayama;H. Ishikawa;N. Ishiguro
我们报告一例65岁男性类风湿性关节炎。患者接受了甲氨蝶呤和强的松龙治疗，但疾病活跃度仍然很高。结核菌素皮肤试验呈阳性。在使用异烟肼进行抗结核化学预防4周后，给予英夫利昔单抗。化学预防持续了9个月。活动性肺结核是在异烟肼停药17个月后，即开始英夫利昔单抗治疗后27个月诊断出来的。这一病例报告表明，在接受抗肿瘤坏死因子治疗的患者进行化学预防后，可以出现结核病。
We report a case of a 65-year-old man with rheumatoid arthritis. The patient was treated with methotrexate and prednisolone, but the disease activity remained high. A tuberculin skin test was positive. After antituberculosis (TB) chemoprophylaxis with isoniazid for four weeks, infliximab was administered. Chemoprophylaxis was continued for nine months. Active lung TB was diagnosed at 17 months after the cessation of isoniazid, namely at 27 months after starting infliximab treatment. This case report shows that TB can manifest after chemoprophylaxis in patients treated with antitumor necrosis factor agents.