SPATIAL AND TEMPORAL CORRELATION BETWEEN EARLY NERVE-FIBER GROWTH AND NEUROEPITHELIAL CELL-DEATH IN THE CHICK-EMBRYO RETINA
SPATIAL AND TEMPORAL CORRELATION BETWEEN EARLY NERVE-FIBER GROWTH AND NEUROEPITHELIAL CELL-DEATH IN THE CHICK-EMBRYO RETINA
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DOI：
10.1007/bf00305042
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发表时间：
1988-01-01
期刊：
影响因子：
--
通讯作者：
RIOS, A
中科院分区：
文献类型：
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作者：
CUADROS, MA;RIOS, A
研究了汉堡-汉密顿病第16 ~ 25期（孵育2 1/2 ~ 4 1/2天）鸡胚视网膜腹侧收缩区的细胞死亡分布。从第20期开始，出现在视网膜上的碎片数量明显增加，在这个阶段，它们几乎完全局限于视盘区域。同时，在这一区域首次发现了光纤。在第24期，视网膜腹侧有大量细胞死亡现象，并在接下来的阶段变得更加广泛。与此同时，在第25阶段，视网膜背侧的细胞死亡率下降。细胞残骸和年轻神经节细胞所呈现的整体图像表明，在19-23期，细胞死亡主要发生在后极神经节细胞和视柄之间的区域。在25期视网膜中，腹侧视网膜的大部分细胞碎片位于裂缝两侧，而在向裂缝发送轴突的过程中，神经节细胞出现在这些变性区外侧（鼻侧和颞侧）。因此，在纤维生长和神经上皮细胞退化之间建立了空间和时间相关性，使我们能够构建关于细胞死亡可能在建立光纤生长的初始模式中发挥作用的假设。
The distribution of cell death in the ventral pycnotic zone of the chick embryo retina was studied in Hamburger-Hamilton''s stages 16 to 25 (2 1/2 to 4 1/2 days of incubation). The number of fragments appearing in the retina increases notably from stage 20 at which stage they are limited almost exclusively to the optic disc region. At the same time optic fibers are seen in this area for the first time. In stage 24 cell death phenomena are numerous in the ventral retina, and become even more extensive in the following stage. Stage 25 meanwhile sees a drop in cell death in the dorsal retina. The overall picture presented by cell remains and young ganglion cells indicates that in stages 19-23 cell death occurs mainly in the zone between the ganglion cells of the posterior pole and the optic stalk. In the stage 25 retina most of the cell fragments of the ventral retina are found on either side of the fissure, while ganglion cells in the process of sending out axons toward the fissure appear laterally (nasally and temporally) to these zones of degeneration. Hence a spatial and temporal correlation is established between fiber growth and neuroepithelial cell degeneration, allowing us to construct a hypothesis with regard to the role that cell death might play in setting up an initial pattern of optic fiber growth.