Risk Factors of Microbial Keratitis in Uganda: A Case Control Study
Risk Factors of Microbial Keratitis in Uganda: A Case Control Study
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DOI：
10.1080/09286586.2019.1682619
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发表时间：
2019-10-24
影响因子：
1.8
通讯作者：
Burton, Matthew J.
中科院分区：
文献类型：
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作者：
Arunga, Simon;Kintoki, Guyguy M.;Burton, Matthew J.
目的：微生物性角膜炎（MK）是全球范围内视力丧失的常见原因，特别是在低收入和中等收入国家。本研究旨在调查乌干达MK的危险因素。研究方法：使用巢式病例对照，我们在2016年12月至2018年3月期间在乌干达南部的两个主要眼科单位招募了健康社区对照的MK患者。对照组按1：1的比例分别匹配病例的年龄、性别和村庄。我们收集了人口统计学、职业、艾滋病毒和糖尿病状况的信息。在STATA 14.1版中，使用多变量条件Logistic回归生成MK风险因素的比值比，并使用似然比检验评估相关性的统计学显著性。结果：共纳入病例对照组215对。病例中的HIV阳性患者为9%，对照组为1%，p = 0.0003。糖尿病病例中7%，对照组中1.4%，p = 0.012。眼外伤为29%，对照组为0%。在校正了年龄、性别和村庄的多变量模型中，HIV（OR 83.5，95%CI 2.01-3456，p = 0.020）、糖尿病（OR 9.38，95%CI 1.48-59.3，p = 0.017）和农业职业（OR 2.60，95%CI 1.21-5.57，p = 0.014）与MK相关。与低社会经济地位相比，中等社会经济地位与MK相关性较小（OR 0.29，95%CI 0.09-0.89，p < .0001）。结论：MK与HIV、糖尿病、贫困、以务农为主有关。需要更多的研究来探索这些因素如何使MK易感。
Purpose: Microbial keratitis (MK), is a frequent cause of sight loss worldwide, particularly in low and middle-income countries. This study aimed to investigate the risk factors of MK in Uganda. Methods: Using a nested case control, we recruited healthy community controls for patients presenting with MK at the two main eye units in Southern Uganda between December 2016 and March 2018. Controls were individually matched for age, gender and village of the cases on a 1:1 ratio. We collected information on demographics, occupation, HIV and Diabetes Mellitus status. In STATA version 14.1, multivariable conditional logistic regression was used to generate odds ratios for risk factors of MK and a likelihood ratio test used to assess statistical significance of associations. Results: Two hundred and fifteen case-control pairs were enrolled. The HIV positive patients among the cases was 9% versus 1% among the controls, p = .0003. Diabetes 7% among the cases versus 1.4% among the controls, p = .012. Eye trauma was 29% versus 0% among the cases and controls. In the multivariable model adjusted for age, sex and village, HIV (OR 83.5, 95%CI 2.01-3456, p = .020), Diabetes (OR 9.38, 95% CI 1.48-59.3, p = .017) and a farming occupation (OR 2.60, 95%CI 1.21-5.57, p = .014) were associated with MK. Compared to a low socio-economic status, a middle status was less likely to be associated with MK (OR 0.29, 95%CI 0.09-0.89, p < .0001). Conclusion: MK was associated with HIV, Diabetes, being poor and farming as the main occupation. More studies are needed to explore how these factors predispose to MK.