Coronary Artery Disease and Reticular Macular Disease, a Subphenotype of Early Age-Related Macular Degeneration.
Coronary Artery Disease and Reticular Macular Disease, a Subphenotype of Early Age-Related Macular Degeneration.
复制标题
DOI：
10.3109/02713683.2015.1128552
复制
发表时间：
2016-11
影响因子：
2
通讯作者：
Smith RT
中科院分区：
文献类型：
--
作者：
Cymerman RM;Skolnick AH;Cole WJ;Nabati C;Curcio CA;Smith RT
网状黄斑病（RMD）是早期黄斑变性的最高风险形式，也特别导致寿命下降。然而，由于RMD需要先进的视网膜成像才能充分检测其特征性的视网膜下类松素沉积（SDD），因此尚未完全研究其与冠状动脉疾病（CAD）的关系，冠心病是发达国家的主要死亡原因。由于CAD多发于中年，我们的目的是筛选年龄在45-80岁之间的有或无CAD记录的患者，以确定CAD是否与RMD相关。一项前瞻性队列研究，在一个机构的临床实践环境中，有CAD记录的患者没有已知的视网膜疾病。来自38例连续患者的76只眼睛（23例有CAD记录，15例对照组无CAD记录，47.4%为女性，平均年龄66.7岁）。对患者进行近红外反射/光谱域光学相干断层扫描，并由两个分级者对RMD和软性水肿的SDD病变进行蒙面评估。有或没有RMD/SDD和软脓。冠心病患者的RMD发生率高于无冠心病患者（相对危险度(RR) =2.1， CI= 1.08-3.95， P=0.03）。CAD与软性醉酒无关联。CAD和RMD之间的特殊关系表明两者的共同系统性原因，值得进一步研究。
Reticular macular disease (RMD) is the highest-risk form of early age-related macular degeneration and also specifically confers decreased longevity. However, because RMD requires advanced retinal imaging for adequate detection of its characteristic subretinal drusenoid deposits (SDD), it has not yet been completely studied with respect to coronary artery disease (CAD), the leading cause of death in the developed world. Because CAD appears in middle age, our purpose was to screen patients aged 45–80 years, documented either with or without CAD, to determine if CAD is associated with RMD. A prospective cohort study of patients with documented CAD status and no known retinal disease in a clinical practice setting at one institution. 76 eyes from 38 consecutive patients (23 with documented CAD, 15 controls documented without CAD; 47.4% female; mean age 66.7 years). Patients were imaged with near infrared reflectance/spectral domain optical coherence tomography and assessed in masked fashion by two graders for the presence of SDD lesions of RMD and soft drusen. Presence or absence of RMD/SDD and soft drusen. RMD was more frequent in patients with CAD vs. those without (Relative Risk (RR) =2.1, CI=1.08–3.95, P=0.03). There was no association of CAD with soft drusen. A specific relationship between CAD and RMD suggests common systemic causes for both and warrants further study.