Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology - assisted reproduction technology
Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology - assisted reproduction technology
复制标题
DOI：
10.3109/09513590.2015.1006616
复制
发表时间：
2015-06-01
影响因子：
2
通讯作者：
Kamenov, Zdravko A.
中科院分区：
文献类型：
--
作者：
Bevilacqua, Arturo;Carlomagno, Gianfranco;Kamenov, Zdravko A.
最近，大量关于哺乳动物配子发生和人类生殖的研究调查了肌醇（Myolns）对卵母细胞和精子细胞质量的影响，因为它可能应用于医学辅助生殖。随着临床和基础研究论文的增多，一些观察结果的意义现在需要在一个坚实而严谨的生理框架下进行解释。在2013年佛罗伦萨国际共识会议上，关于Myo-和d -手肌醇在妇产科的应用，已经回答了一些关于在辅助生殖技术中使用这两种立体异构体的研究问题。现有的临床试验和研究对这些分子的生理和药理作用进行了调查。具体来说，肌醇在卵母细胞成熟和精子细胞功能中的生理参与已经被讨论，提供了以下问题的答案：(1)肌醇是否在生理上参与卵母细胞成熟？(2)肌醇是否参与精子功能的生理过程？(3)在辅助生殖技术周期内肌醇治疗有帮助吗？(4) Myolns与D-chiro-inositol的临床疗效是否有差异？本次会议的结论是根据专家小组的意见得出的，并与所有与会者分享，在本审查文件中进行了总结。
A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (Myolns) on oocyte and sperm cell quality, due to its possible application to medically assisted reproduction. With a growing number of both clinical and basic research papers, the meaning of several observations now needs to be interpreted under a solid and rigorous physiological framework. The 2013 Florence International Consensus Conference on Myo- and D-chiro-inositol in obstetrics and gynecology has answered a number of research questions concerning the use of the two stereoisomers in assisted reproductive technologies. Available clinical trials and studies on the physiological and pharmacological effects of these molecules have been surveyed. Specifically, the physiological involvement of Myolns in oocyte maturation and sperm cell functions has been discussed, providing an answer to the following questions: (1) Are inositols physiologically involved in oocyte maturation? (2) Are inositols involved in the physiology of spermatozoa function? (3) Is treatment with inositols helpful within assisted reproduction technology cycles? (4) Are there any differences in clinical efficacy between Myolns and D-chiro-inositol? The conclusions of this Conference, drawn depending on expert panel opinions and shared with all the participants, are summarized in this review paper.