SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
复制标题
DOI：
10.7150/ijbs.29562
复制
发表时间：
2019-01-01
影响因子：
9.2
通讯作者：
Li, Dong
中科院分区：
文献类型：
--
作者：
Liu, Furao;Xia, Zebin;Li, Dong
胰腺癌（Pancreatic cancer，PC）是世界上最致命的疾病之一，具有早期转移和高死亡率的特点。SWI/SNF复合物的亚基已在许多研究中被鉴定为肿瘤进展的调节剂，但SWI/SNF家族的一个成员SMARCAD 1在胰腺癌中的作用尚未阐明。基于GEO数据库分析和患者来源的胰腺癌组织的免疫组化检测，我们发现SMARCAD 1在胰腺癌组织中更高表达，并且其表达水平与患者的生存时间呈负相关。进一步研究表明SMARCAD 1促进胰腺癌细胞的增殖、迁移、侵袭。从机制上讲，我们首先证明SMARCAD 1通过激活胰腺癌中的Wnt/β-catenin信号通路诱导EMT。我们的研究结果提供了SMARCAD 1在胰腺癌中的作用和潜在机制，这可能是PC疾病诊断或治疗应用的有用标志物。
Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elucidated. Based on analysis of GEO database and immunohistochemical detection of patient-derived pancreatic cancer tissues, we found that SMARCAD1 is more highly expressed in pancreatic cancer tissues and that its expression level negatively correlates with patients' survival time. With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechanistically, we first demonstrate that SMARCAD1 induces EMT via activating Wnt/beta-catenin signaling pathway in pancreatic cancer. Our results provide the role and potential mechanism of SMARCAD1 in pancreatic cancer, which may prove useful marker for diagnostic or therapeutic applications of PC disease.