Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three
Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three
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DOI：
10.1016/j.aller.2011.02.005
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发表时间：
2011-11-01
影响因子：
1.8
通讯作者：
Robertson, C.
中科院分区：
文献类型：
--
作者：
Bjorksten, B.;Ait-Khaled, N.;Robertson, C.
背景：在国际儿童哮喘和过敏研究 (ISAAC) 第三阶段中，我们调查了婴儿期母乳喂养与 6-7 岁儿童哮喘、鼻结膜炎和湿疹症状之间的关系。方法：6-7 岁儿童的父母或监护人填写了有关哮喘、鼻结膜炎和湿疹当前症状以及一系列可能的哮喘危险因素（包括母乳喂养史）的书面调查问卷曾经。使用逻辑回归估计患病率优势比，并根据性别、世界地区、语言、人均国民总收入和其他风险因素进行调整。结果：来自 31 个国家 72 个中心的 206,453 名儿童参与了这项研究。报告的母乳喂养与当前喘息无关，比值比（根据性别、世界地区、语言、人均国民总收入和婴儿期遇到的因素进行调整）为 0.99 (95% CI 0.92-1.05)、当前鼻结膜炎 (OR 1.00、95% CI 0.93-1.08)、当前湿疹 (OR 1.05、 95% CI 0.97-1.12），或严重哮喘症状（OR 0.95，95% CI 0.87-1.05）。然而，母乳喂养与严重鼻结膜炎（OR 0.74，95% CI 0.59-0.94）和严重湿疹（OR 0.79，95% CI 0.66-0.95）的风险降低相关。结论：出生第一年母乳喂养与喘息、鼻结膜炎或湿疹的病史或当前症状之间没有一致的关联。 6-7岁儿童，但可能对后两种情况的严重症状有影响。 (C) 2011 年 SEICAP。由 Elsevier Espana, S.L. 出版版权所有。
Background: In Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), we investigated the relationship between breast feeding in infancy and symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children.Methods: Parents or guardians of 6-7 year old children completed written questionnaires on current symptoms of asthma, rhinoconjunctivitis and eczema, and on a range of possible asthma risk factors including a history of breast feeding ever. Prevalence odds ratios were estimated using logistic regression, adjusted for gender, region of the world, language, per capita gross national income, and other risk factors.Results: In all 206,453 children from 72 centres in 31 countries participated in the study. Reported breast feeding ever was not associated with current wheeze, with an odds ratio (adjusted for gender, region of the world, language, per capita gross national income, and factors encountered in infancy) of 0.99 (95% CI 0.92-1.05), current rhinoconjunctivitis (OR 1.00, 95% CI 0.93-1.08), current eczema (OR 1.05, 95% CI 0.97-1.12), or symptoms of severe asthma (OR 0.95, 95% CI 0.87-1.05). Breast feeding was however associated with a reduced risk of severe rhinoconjunctivitis (OR 0.74, 95% CI 0.59-0.94) and severe eczema (OR 0.79, 95% CI 0.66-0.95).Conclusions: There was no consistent association between breast feeding use in the first year of life and either a history or current symptoms of wheezing, rhinoconjunctivitis or eczema in 6-7 year old children, but possibly an effect on severe symptoms of the latter two conditions. (C) 2011 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.