Effects of exercise on gene-expression profile in the rat hippocampus
Effects of exercise on gene-expression profile in the rat hippocampus
复制标题
DOI：
10.1006/nbdi.2001.0427
复制
发表时间：
2001-12-01
影响因子：
6.1
通讯作者：
Cotman, CW
中科院分区：
文献类型：
--
作者：
Tong, LQ;Shen, H;Cotman, CW
运动对大脑功能有有益的影响，包括促进可塑性和增强学习和记忆能力。以前我们发现，运动增加某些神经营养因子，包括脑源性神经营养因子在大鼠海马的表达。为了进一步探讨这些变化的分子机制，我们使用高密度寡核苷酸微阵列包含探针集代表约5000个基因，分析基因转录水平在大鼠海马自愿运行3周，与久坐不动的动物相比。数据分析采用了一种改进的DNA微阵列数据分析的统计方法Cyber-T。在这里，我们表明，运动导致大量的基因转录水平的变化，其中许多是已知的与神经元活动，突触结构和神经元可塑性。我们的数据表明，运动会引起差异基因表达模式，与大脑功能相关的基因发生显着变化。(C)2001年，爱思唯尔科学。
Exercise has beneficial effects on brain function, including the promotion of plasticity and the enhancement of learning and memory performance. Previously we found that exercise increases the expression of certain neurotrophic factors including brain derived neurotrophic factor in the rat hippocampus. To further explore the molecular mechanisms underlying these changes, we used high-density oligonucleotide microarrays containing probe sets representing approximately 5000 genes to analyze the level of gene transcripts in the hippocampus of rats voluntary running for 3 weeks in comparison with sedentary animals. An improved statistical approach for the analysis of DNA microarray data, Cyber-T, was utilized in data analysis. Here we show that exercise leads to changes in the level of a large number of gene transcripts, many of which are known to be associated with neuronal activity, synaptic structure, and neuronal plasticity. Our data indicate that exercise elicits a differential gene expression pattern with significant changes in genes of relevance for brain function. (C) 2001 Elsevier Science.