Hypersensitivity pneumonitis induced by Trichosporon cutaneum.
Hypersensitivity pneumonitis induced by Trichosporon cutaneum.
复制标题
皮肤毛孢子菌引起的过敏性肺炎。
DOI：
10.1164/arrd.1984.130.3.407
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
S. Araki
中科院分区：
文献类型：
--
作者：
K. Shimazu;M. Ando;T. Sakata;K. Yoshida;S. Araki
我们从过敏性肺炎患者的家中分离出皮肤毛孢子菌，并研究了其在 21 例该病中作为病原体的可能作用。高滴度的抗 T。 21 名患者中有 20 名（95.2%）的血清样本中观察到了皮肤抗体，但在不到 9% 的对照血清样本中仅发现了低滴度。在患者的血清样本中也观察到了抗新型隐球菌抗体，但在大多数样本中，它似乎是与皮肤毛虫抗原的交叉反应。这是因为抗C.新型隐球菌抗体被皮肤毛球菌完全吸收，但抗新型隐球菌抗体被皮肤毛球菌完全吸收。皮肤抗体仅被新生隐球菌部分吸收。此外，没有从患者环境中分离出新型隐球菌。对一名患者进行了皮肤毛虫支气管激发试验，结果呈阳性。我们还在鸟粪中发现了皮肤毛癣菌，其中含有这种生物的营养物质。据我们所知，这是第一份关于皮肤毛虫引起的过敏性肺炎的报告。
We isolated Trichosporon cutaneum from the houses of patients with hypersensitivity pneumonitis and investigated its possible role as an etiologic agent in 21 cases of the disease. A high titer of anti-T. cutaneum antibody was observed in serum samples from 20 (95.2%) of the 21 patients, but only a low titer was found in less than 9% of the control serum samples. Anti-Cryptococcus neoformans antibody was also observed in the patients' serum samples, but it appeared, in most samples, to be a cross-reaction to T. cutaneum antigen. This was because the anti-C. neoformans antibody was completely absorbed with T. cutaneum, but the anti-T. cutaneum antibody was only partly absorbed with C. neoformans. Besides, no C. neoformans was isolated from the patients' environment. A bronchoprovocation test with T. cutaneum was done on one patient, with a positive result. We also found T. cutaneum in bird droppings containing nutrients for this organism. To our knowledge, this is the first report on hypersensitivity pneumonitis induced by T. cutaneum.