Factor and Factor Analysis for TCM Syndromes of Real-World Metabolic Syndrome at Different Age Stage
Factor and Factor Analysis for TCM Syndromes of Real-World Metabolic Syndrome at Different Age Stage
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不同年龄阶段真实代谢综合征的中医证候因素及因素分析
DOI：
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发表时间：
2020
影响因子：
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通讯作者：
Can-dong Li
中科院分区：
文献类型：
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作者：
Shu-Jie Xia;Jing Cai;Jian-xin Chen;Xue-juan Lin;Shu-jiao Chen;Bi-Zhen Gao;Can-dong Li
背景：中医药具有多靶点、整体调节的特点，在防治代谢综合征（MS）方面具有一定的优势。本研究旨在探讨不同年龄组中医证候分布的异同，以促进治疗策略的优化。方法：本研究基于在中国3家医院进行的真实世界调查。收集符合纳入标准的MS病例1262例，分为青年组、中年组和老年组。采用因子分析提取证素，采用K -均值聚类分析进行证型分类。采用频数分析和卡方检验比较各组证候特征。结果：共提取出18个证素，其中性证素11个，位证素7个。痰湿是常见的证素。与中老年组相比，青年组的热、气虚质证素和胃位证素更为明显。中年组肾虚证位证频率高于其他各组。老年组阴虚、血虚证候随年龄增长而增多，肺、胆部位证素增多。结论：多发性硬化症中医证候复杂，可能兼有虚实夹杂的特点。痰湿是MS的主要病理因素。此外，不同年龄段的MS患者可能有不同的证候分布特征。因此，根据MS不同年龄阶段的证候特点，在坚持化痰利湿的同时，采取清热、益气、养阴、补血、调肝、宣肺、运脾、养心、滋肾的方法是合理的。
Background.Traditional Chinese medicine (TCM) has the characteristics of multitarget and overall regulation, which has certain advantages in preventing and treating of metabolic syndrome (MS). The aim of the present study was to evaluate the similarities and differences of TCM syndrome distribution in different age groups to promote the optimization of treatment strategies..Methods.This study was based on a real-world survey conducted in 3 hospitals in China. There are 1262 collected cases of MS meeting the inclusion criteria, which were divided into the young group, middle-aged group, and elderly group. Factor analysis (FA) was conducted for syndrome element extraction, and K -means cluster analysis was processed for syndrome type classification. Frequency analysis and Chi-square test were used to compare the syndrome characteristics of each group..Results.Common factors extracted were assigned to 18 syndrome elements including 11 nature syndrome elements and 7 location syndrome elements. Phlegm and dampness are the most frequent syndrome elements in general. Compared with the middle-aged group and elderly group, the young group has more obvious nature syndrome elements in heat and Qi deficiency, and location syndrome elements in the stomach. As for the middle-aged group, the frequency of location syndrome in kidney syndrome was higher than that in other groups. When it comes to the elderly group, it is shown that the symptoms of Yin deficiency and blood deficiency increase with age and the old patients may have more location syndrome elements in the lung and gallbladder..Conclusion.The TCM syndrome of MS is complex in that there may be the characteristics of deficiency and excess syndrome simultaneously. The main pathological factors of MS were phlegm and dampness. Besides, MS patients at different age periods may have their own syndrome distribution features. So, it is reasonable to adhere to the method of resolving phlegm and removing dampness and, at the same time, adopt the ways of clearing heat, promoting Qi, nourishing Yin, supplementing blood as well as regulating the liver, promoting the lung, transporting the spleen, nourishing the heart, and nourishing the kidney based on the syndrome feature of MS in different age stages.