Prenatal maternal hair cortisol concentrations are related to maternal prenatal emotion dysregulation but not neurodevelopmental or birth outcomes
Prenatal maternal hair cortisol concentrations are related to maternal prenatal emotion dysregulation but not neurodevelopmental or birth outcomes
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DOI：
10.1002/dev.21952
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发表时间：
2020-01-30
影响因子：
2.2
通讯作者：
Crowell, Sheila E.
中科院分区：
文献类型：
--
作者：
Conradt, Elisabeth;Shakiba, Nila;Crowell, Sheila E.
在怀孕期间测量毛发皮质醇浓度已经成为产前压力暴露的一种新的生物标志物。然而，产前压力和痛苦之间的联系，广义的定义，和怀孕期间头发皮质醇浓度是不一致的。我们研究了妊娠晚期头发皮质醇浓度与(a)情绪失调和(b)产妇产前压力的详细测量之间的关系。我们还检查了怀孕期间母亲毛发皮质醇对新生儿不良健康结局的预测有效性。皮质醇浓度来源于怀孕晚期6厘米长的头发。母亲们在这个时候报告了她们的情绪失调和压力。新生儿出生后不久进行了标准化的新生儿神经行为检查，并根据医疗记录评估了新生儿的出生体重和胎龄。所有假设都在开放科学框架（osf.io/279ng）上进行了预注册。高水平的情绪失调，而不是压力，预示着毛发皮质醇浓度高。母体产前BMI介导母体产前情绪失调与毛发皮质醇浓度的关系。毛发皮质醇与婴儿出生结果之间没有关联。这项研究支持了精神病理学的诊断标记是怀孕期间头发皮质醇浓度的重要相关因素的观点。
Hair cortisol concentrations measured during pregnancy have emerged as a novel biomarker for prenatal stress exposure. However, associations between prenatal stress and distress, broadly defined, and hair cortisol concentrations during pregnancy are inconsistent. We examined relations among hair cortisol concentrations during the third trimester with (a) emotion dysregulation and (b) detailed measures of maternal prenatal stress. We also examined the predictive validity of maternal hair cortisol during pregnancy for adverse newborn health outcomes. Cortisol concentrations were derived from 6 cm of hair during the third trimester of pregnancy. Mothers reported on their emotion dysregulation and stress at this time. A standardized newborn neurobehavioral exam was conducted shortly after birth and newborn birth weight and gestational age were assessed from medical records. All hypotheses were preregistered on the Open Science Framework (osf.io/279ng). High levels of emotion dysregulation, but not stress, were predictive of high hair cortisol concentrations. Maternal prenatal BMI mediated the relation between maternal prenatal emotion dysregulation and hair cortisol concentrations. There was no association between hair cortisol and infant birth outcomes. This research supports the notion that transdiagnostic markers of psychopathology are important correlates of hair cortisol concentrations during pregnancy.