Altered resting psychophysiology and startle response in Croatian combat veterans with PTSD.
Altered resting psychophysiology and startle response in Croatian combat veterans with PTSD.
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DOI：
10.1016/j.ijpsycho.2008.10.007
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发表时间：
2009-03
影响因子：
3
通讯作者：
Kozaric-Kovacic, Dragica
中科院分区：
文献类型：
--
作者：
Jovanovic, Tanja;Norrholm, Seth D.;Sakoman, Andrea Jarribrosic;Esterajher, Slavica;Kozaric-Kovacic, Dragica
创伤后应激障碍（PTSD）是对极度创伤经历的长期反应。PTSD的核心症状之一是过度觉醒，这可能是自主神经系统激活升高的结果。在PTSD研究中包括心理生理学评估方法可以指出这种疾病的神经生物学基础。迄今为止，PTSD的心理生理学研究主要是测量反应性。本研究的目的是比较克罗地亚战斗退伍军人样本中PTSD患者和对照组的静息状态心理生理学和惊吓反射。我们测量了心率，呼吸性窦性心律不齐，皮肤电导，眨眼肌肉收缩在适应期和在介绍惊吓刺激在45名男性PTSD患者和33名男性健康对照。我们发现，PTSD患者与对照组相比，基线心率升高，呼吸性窦性心律失常减少。此外，PTSD患者对惊吓探针的习惯性受损，但在初始惊吓程度上没有组间差异。在皮肤电导水平或皮肤电导反应方面也没有组间差异。惊吓习惯和基线心率似乎是PTSD最可靠的心理生理指标。这一发现在新的创伤后应激障碍患者群体中复制了文献中的趋势。
Posttraumatic stress disorder (PTSD) is a prolonged reaction to an extremely traumatic experience. One of the core symptoms of PTSD is hyper-arousal which can be the result of an elevated activation of the autonomic nervous system. Including psychophysiological assessment methods in PTSD research can point to the neurobiological bases of the disorder. The studies of psychophysiology of PTSD to date have mostly measured reactivity. The aim of the current study was to compare resting state psychophysiology and startle reflexes in PTSD patients and controls in a sample of Croatian combat veterans. We measured heart-rate, respiratory sinus arrhythmia, skin conductance, and eyeblink muscle contraction during an acclimation period and during the presentation of startle stimuli in 45 male PTSD patients and 33 male healthy controls. We found that PTSD patient had elevated baseline heart-rate and decreased respiratory sinus arrhythmia compared to the controls. Furthermore, PTSD patients had impaired habituation to the startle probe, but there was no group difference in initial startle magnitude. There was also no group difference in skin conductance level or skin conductance response. Startle habituation and baseline heart-rate appear to offer the most reliable psychophysiological indices of PTSD. This finding replicates trends in the literature in a new population of PTSD patients.
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影响因子：
3.3
作者：
DiGrande, Laura;Perrin, Megan A.;Brackbill, Robert M.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.9
作者：
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通讯作者：
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