(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines
(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines
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DOI：
10.1080/10286020.2021.1952187
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发表时间：
2021-07-04
影响因子：
1.7
通讯作者：
Yang, Zhu-Ya
中科院分区：
文献类型：
--
作者：
Liu, Lu;Li, Xiao-Hong;Yang, Zhu-Ya
（+/-）-Involucrasins A（1）和B（2）是从Shuteria involucrata中分离得到的两对黄烷酮对映体。结构上，1和2都是5-脱羟基/5-脱甲氧基2 ′，3 ′，4 ′-三取代黄烷酮的罕见代表。通过波谱数据分析及与文献数据的比较，确定了化合物的结构。Involucrasin B（2）对Caco-2、MCF-7、MDA-MB-468和HCT 116细胞系表现出中等抗增殖活性，IC 50值范围为7.9-22.7 μ M。Involucrasin A（1）对Caco-2和MCF-7细胞系显示出弱抑制活性，IC 50值分别为25.8和26.5 μ M。
(+/-)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC50 values ranging from 7.9-22.7 mu M. Involucrasin A (1) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC50 values of 25.8 and 26.5 mu M, respectively.