Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk
Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk
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DOI：
10.1001/jama.279.8.593
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发表时间：
1998-02-25
影响因子：
120.7
通讯作者：
Daum, RS
中科院分区：
文献类型：
--
作者：
Herold, BC;Immergluck, LC;Daum, RS
背景。-儿童社区获得性耐甲氧西林金黄色葡萄球菌（MRSA）感染主要发生在具有公认易感风险的个体中。社区获得性MRSA感染在没有确定的危险因素已很少报告。确定社区获得性MRSA感染的儿童没有确定的易感风险是否正在增加，并确定与MRSA分离相关的疾病谱。医疗记录的回顾性审查。病人。- 1988年8月至1990年7月（1988-1990年）和1993年8月至1995年7月（1993-1995年）分离出金黄色葡萄球菌的住院儿童。芝加哥大学儿童医院。主要结果测量。随着时间的推移，社区获得性MRSA的患病率，感染与定植分离株，以及疾病的危险因素。因社区获得性MRSA疾病住院的儿童人数从1988-1990年的8人增加到1993-1995年的35人。此外，社区获得性MRSA的患病率从1988-1990年的10/100000上升到1993-1995年的259/100000（P
Context.-Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in children have occurred primarily in individuals with recognized predisposing risks. Community-acquired MRSA infections in the absence of identified risk factors have been reported infrequently.Objectives.-To determine whether community-acquired MRSA infections in children with no identified predisposing risks are increasing and to define the spectrum of disease associated with MRSA isolation.Design.-Retrospective review of medical records.Patients.-Hospitalized children with S aureus isolated between August 1988 and July 1990 (1988-1990) and between August 1993 and July 1995 (1993-1995).Setting.-The University of Chicago Children's Hospital.Main Outcome Measures.-Prevalence of community-acquired MRSA over time, infecting vs colonizing isolates, and risk factors for disease.Results.-The number of children hospitalized with community-acquired MRSA disease increased from 8 in 1988-1990 to 35 in 1993-1995. Moreover, the prevalence of community-acquired MRSA without identified risk increased from 10 per 100 000 admissions in 1988-1990 to 259 per 100 000 admissions in 1993-1995 (P