Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study
Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study
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DOI：
10.1111/ijpo.12092
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发表时间：
2016-12-01
影响因子：
3.8
通讯作者：
Vrijheid, M.
中科院分区：
文献类型：
--
作者：
Fernandez-Barres, S.;Romaguera, D.;Vrijheid, M.
背景资料：动物模型表明，母亲的饮食质量可能会降低后代肥胖的风险，而不管母亲的体重;然而，来自人类研究的证据是稀缺的。目的：本研究的目的是评估在怀孕期间坚持地中海饮食（MD）与儿童超重和4岁时腹部肥胖风险之间的关联。方法：我们分析了来自西班牙“Infancia y Medio Ambiente”队列研究的1827对母子，这些研究在2003年至2008年期间招募。在怀孕期间使用食物频率问卷和相对地中海饮食评分（rMED）MD坚持饮食进行评估。超重（包括肥胖）定义为年龄特异性和性别特异性体重指数>=第85百分位数（世界卫生组织参考），腹部肥胖定义为腰围（WC）>第90百分位数。结果：妊娠期rMED与体重指数z评分无相关性，但与MD依从性高和WC较低有显著相关性（高与低rMED的β值：-0.62 cm; 95%置信区间：-1.10，-0.14 cm，趋势P =0.009）。结论：妊娠期坚持MD与儿童期超重风险无关，但与较低的WC（腹部肥胖的标志物）相关。
Background: Animal models have suggested that maternal diet quality may reduce offspring obesity risk regardless of maternal body weight; however, evidence from human studies is scarce.Objective: The aim of this study was to evaluate associations between adherence to the Mediterranean diet (MD) during pregnancy and childhood overweight and abdominal obesity risk at 4 years of age.Methods: We analysed 1827 mother-child pairs from the Spanish 'Infancia y Medio Ambiente' cohort study, recruited between 2003 and 2008. Diet was assessed during pregnancy using a food frequency questionnaire and MD adherence by the relative Mediterranean diet score (rMED). Overweight (including obesity) was defined as an age-specific and sex-specific body mass index >= 85th percentile (World Health Organization referent), and abdominal obesity as a waist circumference (WC) >90th percentile. Multivariate adjusted linear and logistic regression models were used to evaluate associations between pregnancy rMED and offspring overweight and abdominal obesity.Result: There was no association between rMED and body mass index z-score, whereas there was a significant association between higher adherence to MD and lower WC (beta of high vs. low rMED: -0.62 cm; 95% confidence interval: -1.10, -0.14 cm, P for trend=0.009).Conclusion: Pregnancy adherence to the MD was not associated with childhood overweight risk, but it was associated with lower WC, a marker of abdominal obesity.