Anterior cingulate and the monitoring of response conflict: Evidence from an fMRI study of overt verb generation
Anterior cingulate and the monitoring of response conflict: Evidence from an fMRI study of overt verb generation
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DOI：
10.1162/089892900562110
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发表时间：
2000-03-01
影响因子：
3.2
通讯作者：
Noll, DC
中科院分区：
文献类型：
--
作者：
Barch, DM;Braver, TS;Noll, DC
对一系列高级认知功能的研究一致地激活了前扣带皮层（ACC）的一个区域，该区域通常位于小脑后角和胼胝体上级。特别是，这ACC区域似乎是活跃的任务的情况下，有必要推翻一个优势的反应倾向，当响应是欠确定的，当错误。我们假设ACC区域的功能是监测不相容反应之间的“串扰”或竞争。在以前的工作中，我们提供了初步的支持这一假设，证明ACC活动在同一地区的错误试验和正确的试验中的任务条件，旨在引起更大的反应竞争。在本研究中，我们扩展我们的测试这一假设的任务情况下，涉及欠定反应。具体而言，14名健康对照受试者在事件相关功能磁共振成像（fMRI）过程中进行了动词生成任务，在线采集明显的言语反应。结果表明，ACC，只有ACC，是更积极的一系列任务条件，引起竞争的替代反应。这些条件包括更大的ACC反应：（1）名词分类为低与高约束（即，在规范化研究中，多个动词以相等的频率产生，而单个动词的产生频率比任何其他动词都高）;（2）产生与特定名词弱关联的动词，而不是与特定名词强关联的动词;以及（3）产生与归类为高约束的名词弱关联的动词。我们讨论了这些结果的含义，了解ACC在人类认知中发挥的作用。
Studies of a range of higher cognitive functions consistently activate a region of anterior cingulate cortex (ACC), typically posterior to the genu and superior to the corpus collosum. In particular, this ACC region appears to be active in task situations where there is a need to override a prepotent response tendency, when responding is underdetermined, and when errors are made. We have hypothesized that the function of this ACC region is to monitor for the presence of "crosstalk" or competition between incompatible responses. In prior work, we provided initial support for this hypothesis, demonstrating ACC activity in the same region both during error trials and during correct trials in task conditions designed to elicit greater response competition. In the present study, we extend our testing of this hypothesis to task situations involving underdetermined responding. Specifically, 14 healthy control subjects performed a verb-generation task during event-related functional magnetic resonance imaging (fMRI), with the on-line acquisition of overt verbal responses. The results demonstrated that the ACC, and only the ACC, was more active in a series of task conditions that elicited competition among alternative responses. These conditions included a greater ACC response to: (1) Nouns categorized as low vs. high constraint (i.e., during a norming study, multiple verbs were produced with equal frequency vs. a single verb that produced much more frequently than any other); (2) the production of verbs that were weak associates, rather than, strong associates of particular nouns; and (3) the production of verbs that were weak associates for nouns categorized as high constraint. We discuss the implication of these results for understanding the role that the ACC plays in human cognition.