Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template
Synthesis of a molecular trefoil knot by folding and closing on an octahedral coordination template
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DOI：
10.1038/nchem.544
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发表时间：
2010-03-01
期刊：
影响因子：
21.8
通讯作者：
Hunter, Christopher A.
中科院分区：
文献类型：
--
作者：
Guo, Jun;Mayers, Paul C.;Hunter, Christopher A.
模板导向合成的出现提供了一系列新的互锁分子结构。虽然分子索烷和轮烷的合成已经有很多报道，但分子结是一类具有拓扑非平面图的分子，其速率相当高。在这里，我们报告了一个灵活的联吡啶低聚物和锌（II）八面体配位模板的分子三叶结的制备的合成策略。低聚物在模板存在下折叠成稳定的开结构象，并且通过酯化或闭环复分解捕获这种排列产生闭结复合物。随后从复分解产物中去除模板导致分子三叶结。
The advent of template-directed synthesis has provided access to a range of new interlocked molecular architectures. Although many syntheses of molecular catenanes and rotaxanes have been reported, molecular knots are a class of molecules with topologically non-planar graphs that are rather rate. Here we report a synthetic strategy for the preparation of a molecular trefoil knot from a flexible bipyridine oligomer and a zinc(II) octahedral coordination template. The oligomer folds into a stable open-knot conformation in the presence of the template, and trapping of this arrangement through esterification or ring-closing metathesis produces the closed-knot complex. Subsequent removal of the template from the metathesis product results in a molecular trefoil knot.